Results 41 to 50 of about 1,894 (158)

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, Volume 604, Issue 13, Page 5629-5662, 1 July 2026.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

A Comparative Study on the Effect of Duloxetine Hydrochloride, Venlafaxine Hydrochloride, and Pregabalin on the Sensory Symptoms in Patients with Diabetic Polyneuropathy

مجله دانشکده پزشکی اصفهان, 2018
Background: Peripheral neuropathic pain is a common disorder in patients with diabetes mellitus, which causes significant disability. Various treatments for this disorder have been proposed.
Naeimeh Kardanpour, Fariborz Khorvash, Farzin Khorvash, Mohammad Memarzadeh   +3 more
doaj   +1 more source

Curative effect of oxycodone sustained-release tablets combined with duloxetine versus paroxetine in treatment of depression and pain from advanced cancer

Di-san junyi daxue xuebao, 2020
Objective To investigate the efficacy and safety of oxycodone sustained-release tablets combined with different types of antidepressants (duloxetine and paroxetine) in the patients suffering from depression and pain due to advanced cancer.
ZENG Yuan, SUN Jianhai
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

ECO-FRIENDLY NON-DERIVATIZED HPLC APPROACH FOR SIMULTANEOUS DETERMINATION OF PREGABALIN, MILNACIPRAN, AND DULOXETINE EMPLOYED IN FIBROMYALGIA TREATMENT [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
A novel, eco-friendly high performance liquid chromatography (HPLC) method was developed for the simultaneous determination of pregabalin (PRE), milnacipran hydrochloride (MIL), and duloxetine hydrochloride (DLU), FDA-approved fibromyalgia drugs.
‪Hussein Ghanem‬‏, Asmaa El- Zaher, Enas Abdelhamed, Sally Tarek Mahmoud   +3 more
doaj   +1 more source

Estimation of duloxetine hydrochloride in pharmaceutical formulations by RP-HPLC method

Indian Journal of Pharmaceutical Sciences, 2008
Simple, specific, accurate and precise method, namely, reverse phase high performance liquid chromatography was developed for estimation of duloxetine HCl in pharmaceutical formulations. For the high performance liquid chromatography method, Phenomenox C-18, 5 μm column consisting of 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.01M
Patel, Sejal K., Patel, N. J., Patel, K. M., Patel, P. U., Patel, B. H.   +4 more
openaire   +3 more sources

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine

Diabetes, Metabolic Syndrome and Obesity, 2010
Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent ...
Russell J, Zilliox L
doaj   +2 more sources

Modulation of Magnetic Resonance Spectroscopy Levels of Glutamate and GABA by Ketamine in Treatment‐Resistant Depression

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
Using magnetic resonance spectroscopy, we show that lower baseline glutamate predicts antidepressant response to ketamine and that responders exhibit greater post‐treatment increases in brain glutamate compared to non‐responders. These findings suggest that glutamatergic capacity for change may underlie ketamine's therapeutic effects in treatment ...
Stephanie Njau, Artemis Zavaliangos‐Petropulu, Shantanu Joshi, John Brooks, Joseph O'Neill, Woods P. Roger, Viviane Norris, Randall T. Espinoza, Katherine L. Narr   +8 more
wiley   +1 more source