Results 41 to 50 of about 213,451 (221)

Tolerability of duloxetine in elderly and in non-elderly adults: a protocol of a systematic review and individual participant data meta-analysis of randomized placebo-controlled trials

open access: yesSystematic Reviews, 2022
Background Duloxetine is an antidepressant that benefits from a wide range of approval in the elderly population, while its safety for use compared to non-elderly is not clearly assessed.
Jean-Charles Roy   +4 more
doaj   +1 more source

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

open access: yesE-Journal of Chemistry, 2010
A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations.
Mohammad Yunoos   +4 more
doaj   +1 more source

N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine

open access: yesActa Crystallographica Section E, 2008
The title compound, C19H21NOS, is an intermediate for the synthesis of duloxetine hydrochloride. In the molecular structure, the thiophene and naphthalene ring systems make a dihedral angle of 87.5°. All bond lengths and angles involving heteroatoms
Jin-Tang Wang   +3 more
doaj   +1 more source

Duloxetine in the Treatment of Women with Urinary Incontinence: A Systematic Review and Meta-analysis of Efficacy Data from Randomized Controlled Clinical Trials

open access: yesJournal of Urological Surgery, 2023
Duloxetine is the only available agent for the medical treatment of stress urinary incontinence (SUI). In this systematic review, we analyzed the efficacy and safety of duloxetine treatment in women with SUI and stress-predominant mixed urinary ...
Naşide Mangır   +5 more
doaj   +1 more source

Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization

open access: yesActa Pharmaceutica Sinica B, 2011
Duloxetine hydrochloride enteric coated pellets were formulated using fluidized bed. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto the inert core pellets.
D. Shravani   +2 more
doaj   +1 more source

Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery

open access: yesInternational Journal of Pharmaceutics: X, 2023
Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited bioavailability due to extensive gastric and first-pass metabolism.
Radwa M.A. Abd-Elal   +7 more
doaj   +1 more source

Polymorphism and a Metastable Solvate of Duloxetine Hydrochloride

open access: yes, 2016
Duloxetine hydrochloride (1) is an important antidepressant that acts as a serotonin and noradrenaline reuptake inhibitor that has only recently been characterized by single-crystal X-ray diffraction.
Anne M. Rich (2070217)   +3 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Pharmacological Influences on the R2 Blink Reflex Response in Healthy Participants: A Systematic Review

open access: yesEuropean Journal of Neuroscience, Volume 64, Issue 3, August 2026.
Pharmacological modulation of the R2 blink reflex was comparable whether responses were elicited using standard patch or concentric electrodes. Across nine studies, noradrenergic and GABAergic interventions produced the most consistent effects, supporting the R2 blink reflex as a sensitive biomarker of trigeminofacial nociceptive processing.
Josh Murphy   +5 more
wiley   +1 more source

Evaluation of duloxetine for chronic pain conditions

open access: yes, 2011
Summary Duloxetine hydrochloride (duloxetine) is used as a nonopioid analgesic for the treatment of certain chronic pain conditions. It is a serotonin and norepinephrine reuptake inhibitor and has been approved in the USA for the management of both ...
Daniel J Walker   +2 more
core   +1 more source

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