Results 61 to 70 of about 213,451 (221)
Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.Using magnetic resonance spectroscopy, we show that lower baseline glutamate predicts antidepressant response to ketamine and that responders exhibit greater post‐treatment increases in brain glutamate compared to non‐responders. These findings suggest that glutamatergic capacity for change may underlie ketamine's therapeutic effects in treatment ...
Stephanie Njau +8 more
wiley +1 more source
, 2014 This open-label pilot study is aimed to evaluate the efficacy and tolerability of the antidepressant duloxetine, which is effective for diabetic neuropathic pain, in the treatment of chronic oxaliplatin-induced peripheral neuropathy (OIPN).
Yang, Ya-Hsu;Lin, Jen-Kou;Chen, Wei-Shone;Lin, Tzu-Chen;Yang, Shung-Haur;Jiang, Jeng-Kai;Chang, Shih-Ching;Lan, Yuan-Tzu;Lin, Chun-Chi;Yen, Chueh-Chuan;Tzeng, Cheng-Hwai;Wang, Wei-Shu;Chiang, Huey-Ling;Teng, Chung-Jen;Teng, Hao-Wei +1 more
core +1 more source
, 1997 Duloxetine hydrochloride, a mixed reuptake inhibitor of serotonin and noradrenaline, was studied in a 6 week open-label uncontrolled multicentre design at a dose of 20 mg daily both in in- and outpatients meeting DSM-III-R criteria for unipolar major ...
Lilly Duloxetine Depression Study Group (13693273) +4 more
core +1 more source
Journal of Analytical Methods in Chemistry, Volume 2026, Issue 1, 2026.N‐nitrosamine (hereinafter nitrosamine) is among the organic impurities characterized by high potency as genotoxic and probable human carcinogens found in drug substances and drug products. This type of impurity has become a major concern in pharmaceutical industry, since one of nitrosamine type of impurities, NDMA, was detected in valsartan active ...
Rimadani Pratiwi +4 more
wiley +1 more source
Journal of Nursing Management, Volume 2026, Issue 1, 2026.Purpose This review aims to synthesize current evidence on perioperative multimodal analgesia within enhanced recovery after surgery (ERAS) pathways for total joint arthroplasty (TJA). The primary objective is to translate this evidence into clear, actionable insights for nursing management and interprofessional collaboration, emphasizing the pivotal ...
Qiuru Wang +8 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
Facile Colorimetric Determination of Duloxetine in Formulations Using Methyl Orange as Ion-Pairing Agent [PDF]
, 2013 Purpose: To develop a new and fully validated ion-pair spectrophotometric method for the determination of duloxetine hydrochloride (DX).Methods: Ion-pair spectrophotometric method was employed for the determination of duloxetine hydrochloride (DX) in ...
Jang, HT +3 more
core +1 more source
Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley +1 more source