Results 61 to 70 of about 3,570 (199)

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
This study compared five antidepressants (paroxetine, sertraline, duloxetine, mirtazapine, and vortioxetine) in mice using EEG/EMG, revealing distinct effects on REM and NREM sleep. The figure illustrates changes in sleep architecture during the light phase (ZT0–12).
Junya Maruoka, Ryo Egami, Yuto Akita, Kohei Kozuka, Yusuke Kakumoto, Tetsuro Kikuchi, Kazuhiko Kume   +6 more
wiley   +1 more source

Measures of fibromyalgia: Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), Multidimensional Fatigue Inventory (MFI‐20), Medical Outcomes Study (MOS) Sleep Scale, and Multiple Ability Self‐Report Questionnaire (MASQ) [PDF]

, 2011
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88107/1/20531_ftp ...
Allen, Arnold, Arnold, Arnold, Arnold, Arnold, Arnold, Banos, Barendregt, Bennett, Bennett, Bennett, Burckhardt, Cappelleri, Cella, Clauw, Cleeland, Cleeland, Coyne, Daut, Dekkers, Donovan, Dworkin, Dworkin, Ericsson, Farrar, Farrar, Fishbain, Hays, Hays, Jansen, Jim, Keller, Lin, Martin, Martin, Mease, Mease, Mease, Mendoza, Owen, Payne, Radbruch, Rejas, Seidenberg, Smets, Smets, Tan, Turk, Unruh, Williams, Williams, Wolfe, Wolfe, Wolfe   +54 more
core   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Curative effect of oxycodone sustained-release tablets combined with duloxetine versus paroxetine in treatment of depression and pain from advanced cancer

Di-san junyi daxue xuebao, 2020
Objective To investigate the efficacy and safety of oxycodone sustained-release tablets combined with different types of antidepressants (duloxetine and paroxetine) in the patients suffering from depression and pain due to advanced cancer.
ZENG Yuan, SUN Jianhai
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

A comparison of duloxetine hydrochloride with fluoxetine hydrochloride in major depressive disorders: a pilot study

Health, 2010
To compare remission rate, relapse rate and tolerability of duloxetine, a dual reuptake inhibitor of 5-hydroxy serotonin (5-HT) and norepinephrine (NE), versus fluoxetine, a reuptake inhibitor of 5-HT during follow up period of 16 weeks in major depressive disorder (MDD) a open label comparative trial was conducted. Trial was comprising of 60 patients,
Ravinder Kumar Sah, Harmeet Singh Rehan, Kannanore Eloremadathil Sadanandan Unni, Deepti Chopra, Seema Manak, Preeta Kaur Narula   +5 more
openaire   +2 more sources

Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects [PDF]

, 2017
In vitro studies showed that CYP2C19, CYP2B6, and CYP1A2 contribute to the metabolism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to 3,4-methylenedioxyamphetamine (MDA).
Liechti, Matthias E., Meyer Zu Schwabedissen, Henriette E., Prestin, Katharina, Schmid, Yasmin, Vizeli, Patrick   +4 more
core   +1 more source

Modulation of Magnetic Resonance Spectroscopy Levels of Glutamate and GABA by Ketamine in Treatment‐Resistant Depression

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
Using magnetic resonance spectroscopy, we show that lower baseline glutamate predicts antidepressant response to ketamine and that responders exhibit greater post‐treatment increases in brain glutamate compared to non‐responders. These findings suggest that glutamatergic capacity for change may underlie ketamine's therapeutic effects in treatment ...
Stephanie Njau, Artemis Zavaliangos‐Petropulu, Shantanu Joshi, John Brooks, Joseph O'Neill, Woods P. Roger, Viviane Norris, Randall T. Espinoza, Katherine L. Narr   +8 more
wiley   +1 more source

Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride [PDF]

Journal of Analytical Science and Technology, 2016
Duloxetine hydrochloride is an antidepressant drug also approved for diabetic neuropathy, anxiety disorders, and fibromyalgia requiring repeated administration on chronic basis. The objective of this study was to develop a transdermal drug delivery system for duloxetine hydrochloride as a once daily dosage form.
Singh, Amandeep, Bali, Alka
openaire   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source