Results 81 to 90 of about 3,570 (199)

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Stability-Indicating RP-HPLC Method Development and Validation for Duloxetine Hydrochloride in Tablets [PDF]

Journal of AOAC INTERNATIONAL, 2010
Abstract This paper describes the development of a stability-indicating RP-HPLC method for duloxetine hydrochloride (DLX) in the presence of its degradation products generated from forced decomposition studies. The drug substance was found to be susceptible to stress conditions of acid, base, oxidation, wet heat, dry heat, and ...
Sejal K, Patel, Natavarlal J, Patel, Arun M, Prajapati, Dipti B, Patel, Satish A, Patel   +4 more
openaire   +2 more sources

Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex [PDF]

, 2018
Rationale: Pupillometry can be used to characterize autonomic drug effects. Objective: This study was conducted to determine the autonomic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), administered alone and after pretreatment with ...
Hysek, Cédric, Liechti, Matthias
core  

Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant‐Like Effects by Modulating the Serotoninergic System in Mouse Models

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
BCBL is a promising dietary supplement for the treatment of depression. Its potential in treating depression was predicted by network pharmacology and verified through systematic experiments. BCBL warrants further investigations and explorations for its safety and efficacy. ABSTRACT Baichuan Baile (BCBL) is a novel formula that incorporates three herbs
Shuai‐Ming Zhu, Chun‐Xue Gao, Zi‐Jia Jin, Fu‐Yao Luo, Ting Feng, Jing‐Cao Li, Yu Yang, Rui Xu, Hao Ma, Chang‐Wei Li, Rui Xue, Jun‐Jie Shan, You‐Zhi Zhang   +12 more
wiley   +1 more source

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database [PDF]

, 2015
Background: Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepressant
A Gross, Antony Arthur, B Wieseler, BD Hayes, C Coupland, C Coupland, C Martinez, CA Coupland, Carol Coupland, CB Nemeroff, D Schmidt, DC Hesdorffer, DC Hesdorffer, DC Hesdorffer, DD Wang, DG Altman, DG Altman, E Kumlien, F Melani, F Pisani, GC Hall, H Mori, J Abraham, JF Tellez-Zenteno, Julia Hippisley-Cox, K Alper, M Koster, M Moore, M Nowak, M Okazaki, Michael Moore, NHS Choices, P Townsend, PC Jobe, PJ Cuenca, Richard Morriss, S Cotterman-Hart, SA Montgomery, Trevor Hill   +38 more
core   +2 more sources

14. Discogenic Low Back Pain

Pain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os, Ricardo Alvarez‐Jimenez, Steven P. Cohen, Milan P. Stojanovic, Ricardo Ruiz‐Lopez, Jan Van Zundert, Jan Willem Kallewaard   +6 more
wiley   +1 more source

QbD-Optimized RP-HPLC Method Development for Simultaneous Quantification of Pregabalin and Duloxetine Hydrochloride

Biophysica
Quality by design (QbD) is a systematic approach focused on achieving consistent, predictable quality based on predefined objectives. Unlike traditional methods, QbD prioritizes risk assessment and management, which significantly enhances the robustness ...
Indu Passi, Ram Kumar, Sushant Salwan, Pooja A. Chawla, Nisha Bansal, Bhupinder Kumar   +5 more
doaj   +1 more source

Is Hearing Impairment Associated With Specific Behavioural and Psychological Symptoms of Dementia in Japanese Older Adults Attending a Memory Clinic?

Psychogeriatrics, Volume 25, Issue 5, September 2025.
ABSTRACT Background Behavioural and psychological symptoms of dementia (BPSD), encompassing disturbances in perception, thought, mood and behaviour, are prevalent among individuals with dementia and can substantially affect their quality of life. Although prior research has suggested that hearing impairment (HI) may exacerbate BPSD due to communication
Saki Tanaka, Ryo Katayose, Teruaki Kawasaki, Ichiro Akiguchi, Mihoko Ogita   +4 more
wiley   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Efficient Syntheses of Diverse, Medicinally Relevant Targets Planned by Computer and Executed in the Laboratory [PDF]

, 2018
The Chematica program was used to autonomously design synthetic pathways to eight structurally diverse targets, including seven commercially valuable bioactive substances and one natural product.
Bauer, Bishop, Bøgevig, Clark, Corey, Crosby, Cruz-Acosta, Currie, Fialkowski, Foote, Gelernter, Getlik, Grzybowski, Hanessian, Hendrickson, Hu, Höllering, Kim, Kowalik, Kuo, Meyer, Miki, Nakamura, Ravitz, Szymkuć, Tadpetch, Ugi, Wu   +27 more
core   +1 more source