Interactions with many clinically active therapeutic agents with DNA are well studied and it is necessary to decipher the structure of DNA and to investigate the pathological implications of those molecules in living organism. This study investigated the interaction of antidepressant drug Duloxetine-hydrochloride (DLX) with calf thymus DNA (ct-DNA ...
Abul Hasnat +7 more
openaire +2 more sources
In this study, two simple and accurate spectrophotometric methods were presented for the determination of duloxetine hydrochloride (DLX) in pharmaceutical preparations. The methods were based on the reaction of DLX as n-electron donor with 2,3-dichloro-5,
Sidika Ertürk Toker, Armagan Önal
doaj +1 more source
Duloxetine in addition to self-management for painful temporomandibular disorders: a post hoc responder analysis of a randomized, placebo-controlled clinical trial [PDF]
Aim To identify the phenotypic characteristics of individuals with temporomandibular disorders (TMD) who may benefit from adding duloxetine to self-management (SM) strategies.
Dyna Mara Araújo Oliveira FERREIRA +5 more
doaj +1 more source
Why study movement variability in autism? [PDF]
Autism has been defined as a disorder of social cognition, interaction and communication where ritualistic, repetitive behaviors are commonly observed. But how should we understand the behavioral and cognitive differences that have been the main focus of
Brincker, Maria, Torres, Elizabeth
core +1 more source
CYTOTOXIC EFFECTS OF DULOXETINE ON MKN45 AND NIH3T3 CELL LINES AND GENOTOXIC EFFECTS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES [PDF]
BACKGROUND: Gastric cancer is the second leading cause of cancer-related death globally. Unfortunately, the survival rate of the gastric cancer patients who underwent chemotherapy following surgery has been less than a half.
Melika HASSANI +4 more
doaj +2 more sources
Pharmacological and Combined Interventions for the Acute Depressive Episode: Focus on Efficacy and Tolerability [PDF]
Background: Use of antidepressants is the gold standard therapy for major depression. However, despite the large number of commercially available antidepressant drugs there are several differences among them in efficacy, tolerability, and cost ...
Brunoni, Andre R +2 more
core
Catalytic asymmetric transfer hydrogenation of ketones: recent advances [PDF]
In this review, we consider the main processes for the asymmetric transfer hydrogenation of ketones from 2008 up today. The most effective organometallic compounds (derived from Ru, Rh, Ir, Fe, Os, Ni, Co, and Re) and chiral ligands (derived from amino ...
Foubelo, Francisco +2 more
core +2 more sources
Pharmacological profile of novel psychoactive benzofurans [PDF]
Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Hoener, Marius C. +3 more
core +1 more source
Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs) [PDF]
4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs).
Hoener, Marius C. +3 more
core +1 more source
Safety pharmacology of acute MDMA administration in healthy subjects [PDF]
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is being investigated in MDMA-assisted psychotherapy. The present study characterized the safety pharmacology of single-dose administrations of MDMA (75 or 125 mg) using data from nine double-blind ...
Liechti, Matthias E., Vizeli, Patrick
core +1 more source

