Results 71 to 80 of about 3,570 (199)
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
Indian Journal of Pharmaceutical Sciences, 2008 A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of duloxetine hydrochloride in pure and pharmaceutical dosage form. Duloxetine hydrochloride showed strong native fluorescence in 0.05 M acetic acid having excitation at 225 nm and emission at 340 nm.
Prabu, S. L. +3 more
openaire +3 more sources
Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetine
Diabetes, Metabolic Syndrome and Obesity, 2010 Lindsay Zilliox1, James W Russell1,21Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, 2VA Maryland Health Care System, Baltimore, MD, USAIntroduction: Neuropathy is one of the most frequent ...
Lindsay Zilliox +1 more
doaj +2 more sources
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley +1 more source
Longitudinal Observation of Treatment Patterns and Outcomes for Patients with Fibromyalgia: 12‐Month Findings from the REFLECTIONS Study [PDF]
, 2013 Objective To describe 12‐month treatment patterns and outcomes for patients starting a new medication for fibromyalgia in routine clinical practice. Design and Outcome Measures Data from 1,700 patients were collected at baseline and 1, 3, 6, and 12 ...
Chen, Yi +9 more
core +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley +1 more source
Native proteins in organic chemistry. Recent achievements in the use of non hydrolytic enzymes for the synthesis of pharmaceuticals [PDF]
, 2016 Financial support by the Spanish Ministerio de Economia y Competitividad (MINECO) through the CTQ-2013-44153-P project is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +2 more
core +2 more sources
Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms
Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum +4 more
wiley +1 more source
MDMA enhances "mind reading” of positive emotions and impairs "mind reading” of negative emotions [PDF]
, 2018 Rationale: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) increases sociability. The prosocial effects of MDMA may result from the release of the "social hormone” oxytocin and associated alterations in the processing of socioemotional stimuli ...
Domes, Gregor +2 more
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