Results 71 to 80 of about 213,451 (221)

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis

Brain and Behavior
Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain.
Abdulsalam Mohammed Aleid, Faisal Alshehri, Naif Alasiri, Fatimah Alhomoud, Shouq Alsaegh, Mohammed Alrasheed, Salem Aljaddua, Ali Alasiri, Asma Boukhari, Abdulmonem Ali Alhussain, Bipin Chaurasia, Saud Nayef Aldanyowi   +11 more
doaj   +1 more source

ANALYTICAL QUALITY BY DESIGN-DRIVEN DEVELOPMENT AND VALIDATION OF A STABILITY-INDICATING RP-UPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DULOXETINE HYDROCHLORIDE AND PREGABALIN IN BULK AND PHARMACEUTICAL DOSAGE FORM

Asian Journal of Pharmaceutical and Clinical Research
Objective: The present study aimed to validate and develop a robust, stability-indicating Reversed Phase-Ultra Performance Liquid Chromatography (RP-UPLC) method for the concurrent determination of Pregabalin and Duloxetine Hydrochloride using the ...
Ankitha M, Ranganath Mk, Chaithanya Sudha Pd   +2 more
semanticscholar   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Comparison of the Efficacy of Duloxetine Versus Pregabalin for Pain Relief of Neuropathy in Diabetics

Pakistan Journal of Medicine and Dentistry
Background: Neuropathy is a common complication in diabetic patients with clinical manifestations of feet and hands paresthesia, pain in the lower legs, and a burning sensation in the soles. A wide variety of medications are used for diabetic neuropathy
Hamid Raza Gulzar, Nosheen Zahoor, Ambreen Zahoor, Hina Saghir, Mariam Tariq, Asma Bibi   +5 more
doaj   +1 more source

Isocratic Reversed-Phase HPLC Assay for the Simultaneous Estimation of Duloxetine Hydrochloride and Derivatized Pregabalin in Combined Pharmaceutical Formulations

Journal of Pharma Insights and Research
A validated isocratic reversed-phase high-performance liquid chromatography assay was developed for the simultaneous determination of duloxetine hydrochloride and pregabalin in combined pharmaceutical formulations.
Devi Sireesha Valluri, Sai Krishna N, A. A, S. P. K. Ponnaganti   +3 more
semanticscholar   +1 more source

Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant‐Like Effects by Modulating the Serotoninergic System in Mouse Models

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
BCBL is a promising dietary supplement for the treatment of depression. Its potential in treating depression was predicted by network pharmacology and verified through systematic experiments. BCBL warrants further investigations and explorations for its safety and efficacy. ABSTRACT Baichuan Baile (BCBL) is a novel formula that incorporates three herbs
Shuai‐Ming Zhu, Chun‐Xue Gao, Zi‐Jia Jin, Fu‐Yao Luo, Ting Feng, Jing‐Cao Li, Yu Yang, Rui Xu, Hao Ma, Chang‐Wei Li, Rui Xue, Jun‐Jie Shan, You‐Zhi Zhang   +12 more
wiley   +1 more source

Duloxetine: A Review of Its Safety and Efficacy in the Management of Fibromyalgia Syndrome

, 2010
Fibromyalgia (FM) is a chronic disorder characterized by widespread pain and other associated symptoms including fatigue, insomnia, cognitive/memory problems, and even psychological distress. Duloxetine is one of three FDA approved medications (the other
Joshua M. Smith, Howard S. Smith, Donna Bracken   +2 more
core   +1 more source

Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Postoperative pain management is considered as a part of recovery. Duloxetine (DLX), an anti-depressant medication, is a possible choice for the multimodal anesthetic strategy.
H Sattari, M Noroozi, M Hashemian, MR Doroodian, F Mansoori Nasab   +4 more
doaj  

14. Discogenic Low Back Pain

Pain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os, Ricardo Alvarez‐Jimenez, Steven P. Cohen, Milan P. Stojanovic, Ricardo Ruiz‐Lopez, Jan Van Zundert, Jan Willem Kallewaard   +6 more
wiley   +1 more source