Results 51 to 60 of about 1,894 (158)

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li, Fangfang Li, Yang Tang, Siyu Guo, Yihan Yao, Yuan Fang, Bicheng Zhang, Yu Jiang, Jing Wang, Dang Wu, Jianxia Cheng, Zhihui Huang, Zengfeng Xin, Ting Zhang   +13 more
wiley   +1 more source

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Electrochemical determination of duloxetine hydrochloride at gold electrode [PDF]

, 2022
Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the uptake of serotonin and norepinephrine. The electrochemical behavior of D U L was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold electrode by varying pH and scan rate. The electroanalytical application was studied with the aid of differential pulse
Lović, Jelena, Mijin, Dušan, Bogdanović, Aleksandra, Vuković, Dragan, Petrović, Slobodan, Avramov - Ivić, Milka   +5 more
openaire  

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

QbD-Optimized RP-HPLC Method Development for Simultaneous Quantification of Pregabalin and Duloxetine Hydrochloride

Biophysica
Quality by design (QbD) is a systematic approach focused on achieving consistent, predictable quality based on predefined objectives. Unlike traditional methods, QbD prioritizes risk assessment and management, which significantly enhances the robustness ...
Indu Passi, Ram Kumar, Sushant Salwan, Pooja A. Chawla, Nisha Bansal, Bhupinder Kumar   +5 more
doaj   +1 more source

Baichuan Baile Formula, a Promising Herbal Dietary Supplement, Exerts Antidepressant‐Like Effects by Modulating the Serotoninergic System in Mouse Models

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
BCBL is a promising dietary supplement for the treatment of depression. Its potential in treating depression was predicted by network pharmacology and verified through systematic experiments. BCBL warrants further investigations and explorations for its safety and efficacy. ABSTRACT Baichuan Baile (BCBL) is a novel formula that incorporates three herbs
Shuai‐Ming Zhu, Chun‐Xue Gao, Zi‐Jia Jin, Fu‐Yao Luo, Ting Feng, Jing‐Cao Li, Yu Yang, Rui Xu, Hao Ma, Chang‐Wei Li, Rui Xue, Jun‐Jie Shan, You‐Zhi Zhang   +12 more
wiley   +1 more source

14. Discogenic Low Back Pain

Pain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os, Ricardo Alvarez‐Jimenez, Steven P. Cohen, Milan P. Stojanovic, Ricardo Ruiz‐Lopez, Jan Van Zundert, Jan Willem Kallewaard   +6 more
wiley   +1 more source

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis

Brain and Behavior
Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain.
Abdulsalam Mohammed Aleid, Faisal Alshehri, Naif Alasiri, Fatimah Alhomoud, Shouq Alsaegh, Mohammed Alrasheed, Salem Aljaddua, Ali Alasiri, Asma Boukhari, Abdulmonem Ali Alhussain, Bipin Chaurasia, Saud Nayef Aldanyowi   +11 more
doaj   +1 more source