Results 91 to 100 of about 171,025 (297)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Introducing Novel Surgical Clinical Correlations Into an Undergraduate Medical Anatomy Course

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Anatomy education is a hallmark of many preclinical medical school curricula, but students are often unable to identify the clinical relevance of anatomy and its applications. Vertical curricula that integrate clinical concepts into the preclinical basic science years and vice versa have been shown to benefit student learning and increase ...
Liam McLoughlin   +5 more
wiley   +1 more source

Peritoneal Recesses of Human Duodenum [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
P.A. Nandagopalan   +2 more
doaj   +1 more source

Anti‐inflammatory and Gastroprotective Effects of the Chamaerops humilis L. (DOUM) Fruit Aqueous Extract in Experimental Models of Edema and Gastric Ulcer

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Chronic inflammation can lead to various diseases, including gastric ulcers, highlighting the need for effective therapeutic strategies. The traditional use of Chamaerops humilis in Moroccan folk medicine for treating gastrointestinal disorders underscores its potential as a valuable natural remedy.
Yasmina Jaouhari   +12 more
wiley   +1 more source

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr   +4 more
wiley   +1 more source

Life-threatening Gastrointestinal Bleeding from a Dieulafoy’s Lesion in the Duodenum: A Case Report

open access: yesThe Korean Journal of Gastroenterology
Dieulafoy’s lesion is a rare cause of gastrointestinal bleeding, accounting for approximately 1–2% of all cases of gastrointestinal bleeding. Dieulafoy’s lesion usually occurs in the lesser curvature of the stomach within six centimeters of the ...
Jun Hyuk Son
doaj   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe   +4 more
wiley   +1 more source

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