Results 161 to 170 of about 14,376 (241)

Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein

The FEBS Journal, EarlyView.
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine-Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions. [PDF]

Angew Chem Int Ed Engl
Huxley C, Fung E, Singh B, Caballero-García G, Muir G, Silverman SM, Campeau LC, Britton R.   +7 more
europepmc   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Towards an Improved Standard in Penile Duplex Doppler Ultrasonography: A Randomized Crossover Trial of 3D Virtual Glasses for Audiovisual Sexual Stimulation. [PDF]

J Clin Med
Park TY, Hwang JY, Yun SW, Jin HJ, Yoon SG, Noh TI, Shim JS, Kang SG, Kang SH, Park MG.   +9 more
europepmc   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency. [PDF]

Front Genet
Sajjad M, Kwon SG.
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Interfacing B-DNA and DNA Mimic Foldamers. [PDF]

Angew Chem Int Ed Engl
Loos M, Xu F, Mandal PK, Chakrabortty T, Douat C, Konrad DB, Cabbar M, Singer J, Corvaglia V, Carell T, Huc I.   +10 more
europepmc   +1 more source

Unity or Distinction? Herman Bavinck’s Use of John Calvin and Later Reformed Orthodoxy in His Doctrine of the Two States

International Journal of Systematic Theology, EarlyView.
Abstract This article examines the doctrine of Christ’s two states of humiliation and exaltation in Herman Bavinck’s and John Calvin’s thought, with the aim of illuminating Bavinck’s use of Calvin. The article begins by exploring Calvin’s use of the two states and argues that his treatment of Christ’s descent into hell is an important though ...
Sarah Killam Crosby
wiley   +1 more source

Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages. [PDF]

Nucleic Acids Res
Dhara D, Hill AC, Ramesh A, Traore D, Radzikowska-Cieciura E, Wood MJA, Brown T.   +6 more
europepmc   +1 more source