Results 21 to 30 of about 179,303 (236)

A Quality‐Driven Framework for Local Fatigue‐Strength Assessment of Wind–Energy Structures Considering Size Effects

Wind Energy
Reliability, safety, and the lifetime of wind energy systems are mainly driven by the quality of each single component. Especially, large structures made of cast material or welded structures, such as the nacelle, the machine carrier, or the tower, are ...
Christoph Bleicher, Jörg Baumgartner, Jan Niewiadomski, Christian Pittel   +3 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Experimental and numerical analyses of stiffness and fatigue properties of a spring element for mounts with tunable stiffness made of C85S+QT sheet steel

Fracture and Structural Integrity
Mounting stiffness has an important impact on a system’s structural dynamics and also on the durability of many structures. Mounts with tunable stiffness allow adapting a system’s structural dynamic behavior.
Volker Landersheim, Cedric Mathieu, Jan Hansmann, William Kaal   +3 more
doaj   +1 more source

Effect of Fly Ash as Cement Replacement on Chloride Diffusion, Chloride Binding Capacity, and Micro-Properties of Concrete in a Water Soaking Environment

Applied Sciences, 2020
This paper experimentally studies the effects of fly ash on the diffusion, bonding, and micro-properties of chloride penetration in concrete in a water soaking environment based on the natural diffusion law.
Jun Liu, Jiaying Liu, Zhenyu Huang, Jihua Zhu, Wei Liu, Wei Zhang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Durability

Citation: 'durability' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13904 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Alireza Akhavan-Safar, Lucas F.M. da Silva   +1 more
  +6 more sources

Corrosión atmosférica del acero suave

Revista de Metalurgia, 2011
La corrosión atmosférica del acero suave es un tema de gran amplitud que ha sido tratado por muchos autores en numerosas regiones del mundo. Este artículo de compilación incorpora publicaciones relevantes sobre esta temática, en particular sobre la ...
M. Morcillo, D. de la Fuente, I. Díaz, H. Cano   +3 more
doaj   +1 more source