Results 31 to 40 of about 1,028,846 (258)
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Dust Formation in Milky Way-like Galaxies [PDF]
, 2015 We introduce a dust model for cosmological simulations implemented in the moving-mesh code AREPO and present a suite of cosmological hydrodynamical zoom-in simulations to study dust formation within galactic haloes. Our model accounts for the stellar production of dust, accretion of gas-phase metals onto existing grains, destruction of dust through ...
arxiv +1 more source
The Astrophysical Journal, 2013 Spitzer Space Telescope and Herschel Space Observatory imaging of M31 is used, with a physical dust model, to construct maps of dust surface density, dust-to-gas ratio, starlight heating intensity, and PAH abundance, out to R=25kpc. The global dust mass is M_d=5.4x10^7Msol, the global dust/H mass ratio is M_d/M_H=0.0081, and the global PAH abundance is
Adam K. Leroy +12 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
The dust content of galaxies from z = 0 to z = 9 [PDF]
, 2016 We study the dust content of galaxies from $z=0$ to $z=9$ in semi-analytic models of galaxy formation that include new recipes to track the production and destruction of dust. We include condensation of dust in stellar ejecta, the growth of dust in the interstellar medium (ISM), the destruction of dust by supernovae and in the hot halo, and dusty winds
arxiv +1 more source
Twisted Dust Acoustic Waves in Dusty Plasmas [PDF]
Phys. Plasmas 19, No. 9, 2012, 2012 We examine linear dust acoustic waves (DAWs) in a dusty plasma with strongly correlated dust grains, and discuss possibility of a twisted DA vortex beam carrying orbital angular momentum (OAM). For our purposes, we use the Boltzmann distributed electron and ion density perturbations, the dust continuity and generalized viscoelastic dust momentum ...
arxiv +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
On the dust abundance gradients in late-type galaxies: II. Analytical models as evidence for massive interstellar dust growth in SINGS galaxies [PDF]
, 2012 We use simple analytical models of the build up of the dust component and compare these with radial dust distributions derived from observations of SINGS galaxies. The observations show that dust gradients are indeed typically steeper than the corresponding metallicity gradients and our models indicate very little dust destruction, but significant dust
arxiv +1 more source