Results 41 to 50 of about 418,423 (300)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Tools of the trade: leveraging 3D in vitro models to advance silicosis research

Frontiers in Pharmacology
Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems.
Ellen Donohoe, Sakthi Priya Selvamani, Sakthi Priya Selvamani, Vivek Dharwal, Vivek Dharwal, Richard Zelei, Richard Zelei, Anthony Linton, Anthony Linton, Anthony Linton, Deborah Yates, Deborah Yates, Deborah Yates, Deborah Yates, Elham Hosseini-Beheshti, Elham Hosseini-Beheshti   +15 more
doaj   +1 more source

Assessment of solar radiation distribution in indoor spaces for local thermal comfort evaluation [PDF]

E3S Web of Conferences
Shortwave solar radiation significantly influences local thermal comfort in indoor environments, particularly in spaces with large glazed areas. Although building performance simulation tools such as EnergyPlus accurately predict solar gains at the room ...
Grygierek Krzysztof, Ferdyn-Grygierek Joanna, Kocik Stanisław, Lipczynska Aleksandra   +3 more
doaj   +1 more source

Minor effect of physical size sorting on iron solubility of transported mineral dust [PDF]

, 2011
Observations show that the fractional solubility of Fe (FS-Fe, ratio of dissolved to total Fe) in dust aerosol increases dramatically from ~0.1% in regions of high dust mass concentration to 80% in remote regions where concentrations are low.
G. Fones, Drake, N, N. Drake, Fones, G., Brooks, B., Carslaw, KS, Jickells, T. D., Drake, N., Krom, MD, Fones, Gary, Jickells, TD, G. W. Mann, B. Brooks, Mann, GW, Brooks, B, Benning, L. G., Woodhouse, M. T., Baker, AR, G. R. Fones, Shi, Z. B., Baker, A. R., Carslaw, K. S., Z. B. Shi, M. D. Krom, L. G. Benning, Savov, I, T. D. Jickells, Shi, Zongbo; id_orcid, Krom, M. D., K. S. Carslaw, Benning, LG, Fones, G. R., A. R. Baker, Woodhouse, M. T, Savov, I., M. T. Woodhouse, Mann, G. W., Fones, GR, I. Savov, Woodhouse, MT   +39 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A combination of PD-1 and TIGIT immune checkpoint inhibitors elicits a strong anti-tumour response in mesothelioma

Journal of Experimental & Clinical Cancer Research
Background Finding effective and curative treatment for mesothelioma remains challenging. While the introduction of immunotherapy combinations using ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have offered hope for some patients, a large ...
Huaikai Shi, Ta-Kun Yu, Ben Johnson, Sakthi Priya Selvamani, Ling Zhuang, Kenneth Lee, Sonja Klebe, Samuel Smith, Kirby Wong, Kate Chen, Georgina Clark, Emma M. Rath, Holly Pearson, David Gallego Ortega, Anthony Linton, Steven Kao, Pablo Silveira, Yuen Yee Cheng   +17 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Global dust model intercomparison in AeroCom phase I [PDF]

, 2011
This study presents the results of a broad intercomparison of a total of 15 global aerosol models within the AeroCom project. Each model is compared to observations related to desert dust aerosols, their direct radiative effect, and their impact on the ...
Schulz, M., Sub Atmospheric physics and chemistry, Huneeus, N., Griesfeller, J., Zender, C.S., Krol, M.C., Marine and Atmospheric Research, Balkanski, Y., Takemura, T., F. Dentener, ZENDER C, Dentener, F, HOROWITZ L. W., Miller, R., M. Chin, Horowitz, L., W. Landing, DIEHL T. L., S. Kinne, Prospero, J., MILLER R., C. S. Zender, GRIESFELLER J., Chin, M, EASTER R., KOCH D. M., J. Perlwitz, Ginoux, P, Ginoux, P., Dentener, F., Zender, C. S, STIER Phillip, J. Penner, Schulz, M, S. Bauer, Perlwitz, J, Kinne, S., Ghan, S., PERLWITZ J., Krol, MC, Liu, X, Morcrette, J-J, J. Prospero, T. Takemura, Koch, D, N. Mahowald, Fillmore, D., Horowitz, L, CHIN M., D. Koch, Prospero, J, M. Schulz, G. Myhre, Perlwitz, J., Landing, W., Zender, C., J.-J. Morcrette, A. Grini, DENTENER Franciscus, FILLMORE D., Morcrette, J.-J., O. Boucher, Mahowald, N.,, N. Huneeus, Boucher, O, P. Ginoux, Ghan, S, Prospero, M., Easter, R, GRINI Alessandro, Krol, M., R. Easter, MYHRE G., J. Griesfeller, BOUCHER Olivier, Mahowald, N, BALKANSKI Yves, TAKEMURA T., Penner, J, M. C. Krol, Chin, M., PROSPERO J., Zender, C. S., D. Fillmore, Balkanski, Yves, GHAN S., Balkanski, Y, Zender, CS, KINNE S., Morcrette, J., Fillmore, D, Bauer, S., LANDING W, SCHULZ Michael, Y. Balkanski, Grini, A., S. Ghan, Myhre, G., Kinne, S, Krol, M. C, Griesfeller, J, GINOUX P., KROL Maarten, Boucher, O., MAHOWALD Natalie M., Liu, X., Penner, J., Koch, D., Grini, A, PENNER J. E., L. Horowitz, Takemura, T, T. Diehl, HUNEEUS N, BAUER S., Landing, W, Stier, P., Myhre, G, Huneeus, N, LIU X, MOCRETTE J.J, R. Miller, Mahowald, N., M, Bauer, S, X. Liu, P. Stier, Krol, M. C., Diehl, T., Stier, Philip, Mahowald, N., Miller, R, Easter, R., Diehl, T   +132 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TURAAB: A 34‐Year Dust and Atmospheric Regional Reanalysis for the Middle East, North Africa and Mediterranean—First Insights

Meteorological Applications
The Mediterranean, Middle East and North Africa (MENA) region exhibits distinctive climate behavior, shaped by complex topography and large‐scale circulation, while warming and aridification intensify extremes.
Platon Patlakas, Ioannis Chaniotis, Christos Stathopoulos, Zakiah Alhajji, Ishaq Dimeji Sulaymon, Alaa Mhawish, Jumaan Alqahtani   +6 more
doaj   +1 more source