Results 41 to 50 of about 404,878 (290)

Assessment of solar radiation distribution in indoor spaces for local thermal comfort evaluation [PDF]

E3S Web of Conferences
Shortwave solar radiation significantly influences local thermal comfort in indoor environments, particularly in spaces with large glazed areas. Although building performance simulation tools such as EnergyPlus accurately predict solar gains at the room ...
Grygierek Krzysztof, Ferdyn-Grygierek Joanna, Kocik Stanisław, Lipczynska Aleksandra   +3 more
doaj   +1 more source

Numerical Analysis of the Energy Consumption of Ventilation Processes in the School Swimming Pool

Energies, 2021
Ventilation of an indoor swimming pool is a very energy consuming process. This is a result of, among other things the required high value of the ventilation air volume flow rate, calculated on the basis of the moisture gains in the facility.
Piotr Ciuman, Jan Kaczmarczyk
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tools of the trade: leveraging 3D in vitro models to advance silicosis research

Frontiers in Pharmacology
Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems.
Ellen Donohoe, Sakthi Priya Selvamani, Sakthi Priya Selvamani, Vivek Dharwal, Vivek Dharwal, Richard Zelei, Richard Zelei, Anthony Linton, Anthony Linton, Anthony Linton, Deborah Yates, Deborah Yates, Deborah Yates, Deborah Yates, Elham Hosseini-Beheshti, Elham Hosseini-Beheshti   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stratospheric dust collection by DUSTER (Dust in The Upper Stratosphere Tracking Experiment and Retrieval), a balloon-borne instrument, and laboratory analyses of collected dust. [PDF]

, 2010
The subject of this work is focused on the study of stratospheric dust with DUSTER (Dust in the Upper Stratosphere Tracking Experiment and Retrieval) a balloon-borne instrument.
Ciucci, Alessandra
core   +1 more source

A combination of PD-1 and TIGIT immune checkpoint inhibitors elicits a strong anti-tumour response in mesothelioma

Journal of Experimental & Clinical Cancer Research
Background Finding effective and curative treatment for mesothelioma remains challenging. While the introduction of immunotherapy combinations using ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have offered hope for some patients, a large ...
Huaikai Shi, Ta-Kun Yu, Ben Johnson, Sakthi Priya Selvamani, Ling Zhuang, Kenneth Lee, Sonja Klebe, Samuel Smith, Kirby Wong, Kate Chen, Georgina Clark, Emma M. Rath, Holly Pearson, David Gallego Ortega, Anthony Linton, Steven Kao, Pablo Silveira, Yuen Yee Cheng   +17 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of coal dust particle size after spraying dust reduction in roadway based on orthogonal experiment and regression analysis

Meitan kexue jishu
In order to investigate the main factors affecting the effect of spray dust reduction on the particle size of coal dust after spray dust reduction, a quantitative mathematical model was obtained to characterize the quantitative relationship between the ...
Bingyou JIANG, Yuqian ZHANG, Changfei YU, Ben JI, Haoyu WANG, Zhuang LIU   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source