Results 1 to 10 of about 11,574 (132)

Gefitinib and Fostamatinib Target EGFR and SYK to Attenuate Silicosis: A Multi-Omics Study With Drug Exploration

Signal Transduction and Targeted Therapy, 2022
Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress.
Junling Pang, Juntao Yang, Hao Yang
exaly   +2 more sources

Health and safety in 3D printing

International Journal of Occupational and Environment Safety, 2022
Fused deposition modelling, or 3D printing, is an additive manufacturing technique that is quickly gaining popularity because of its ability to produce usable parts with several geometries. It provides multiple advantages in everyday life.
Héctor García, Teresa López Pola
doaj   +1 more source

Particulate Matter Characterization in a Hospital’s Underground Car Park

Powders, 2022
The air quality in a hospital’s underground car park is a concern because diesel fumes from cars impact upon vulnerable people attending medical consultations. This research aims to quantify the potential health risk associated with a particular hospital
Hector Garcia-Gonzalez, Maida Domat, Teresa Lopez-Pola, Pilar Fernandez-Rubio, Pablo Fernandez-Rodriguez   +4 more
doaj   +1 more source

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

PLoS Genetics, 2022
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin   +12 more
doaj   +2 more sources

Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment

Frontiers in Genetics, 2021
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang, Ya Luo, Dong Wei, Zhujie Cao, Xianmei Qi, Meiyue Song, Ying Liu, Zhaoguo Li, Jin Zhang, Baicun Li, Jingyu Chen, Jingyu Chen, Jing Wang, Chen Wang   +13 more
doaj   +1 more source

The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis

BMC Immunology, 2022
Background Tuberculosis infection is a major complication of silicosis, but there is no study on whether silicosis can affect the sensitivity of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays.
Xin Yu, Li-Na Huang, Jun-Chi Xu, Yi-Yan Song, Hui Chen, Cui-Lin Shi, Pei-Jun Tang, Tao Tao, Ye-Han Zhu   +8 more
doaj   +1 more source

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

BMC Pulmonary Medicine, 2021
Background Silicosis is a progressive pneumoconiosis characterized by interstitial fibrosis following exposure to silica dust. The role of metabolic dysregulation in the pathogenesis of silicosis has not been investigated in detail.
Changjiang Xue, Na Wu, Yali Fan, Jing Ma, Qiao Ye   +4 more
doaj   +1 more source

Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related HLA-DQB1 Gene Associated With Occupational Pulmonary Fibrosis Risk: A Multi-Stage Study

Frontiers in Immunology, 2022
ObjectiveTo evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility.MethodsA comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood ...
Yan Zhou, Yingyi Zhang, Rui Zhao, Zhounan Cheng, Minzhu Tang, Anni Qiu, Yang Dong, Yihua Lu, Yulong Lian, Xun Zhuang, Tian Tian, Wei Wang, Minjie Chu   +12 more
doaj   +1 more source

Silicosis, progressive massive fibrosis and silico-tuberculosis among workers with occupational exposure to silica dusts in sandstone mines of Rajasthan state: An urgent need for initiating national silicosis control programme in India

Journal of Family Medicine and Primary Care, 2021
Context: Silicosis is a progressive, irreversible and incurable respiratory morbidity and often becomes a cause for pre-mature mortality among occupationally silica dust-exposed workers in India and similar countries.
Subroto S Nandi, Sarang V Dhatrak, Kamalesh Sarkar   +2 more
doaj   +1 more source

Social determinants of an occupational lung disease: Workers’ narratives on silicosis

SSM: Qualitative Research in Health, 2023
Silicosis is a preventable occupational lung disease caused by inhaled silica dust. Solutions to prevent silicosis ranging from engineering controls to respirator use have been validated for nearly a century, but many workers are still at-risk of this ...
Yanni Liang, Katherine E. McCoy, Carrie D. Tomasallo, Jonathan G. Meiman   +3 more
doaj   +1 more source