Results 21 to 30 of about 28,331 (250)

Health and safety in 3D printing

International Journal of Occupational and Environment Safety, 2022
Fused deposition modelling, or 3D printing, is an additive manufacturing technique that is quickly gaining popularity because of its ability to produce usable parts with several geometries. It provides multiple advantages in everyday life.
Héctor García, Teresa López Pola
doaj   +1 more source

Particulate Matter Characterization in a Hospital’s Underground Car Park

Powders, 2022
The air quality in a hospital’s underground car park is a concern because diesel fumes from cars impact upon vulnerable people attending medical consultations. This research aims to quantify the potential health risk associated with a particular hospital
Hector Garcia-Gonzalez, Maida Domat, Teresa Lopez-Pola, Pilar Fernandez-Rubio, Pablo Fernandez-Rodriguez   +4 more
doaj   +1 more source

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

PLoS Genetics, 2022
Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and ...
Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin   +12 more
doaj   +2 more sources

Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis Treatment

Frontiers in Genetics, 2021
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, which may not perfectly reflect the nature of human
Junling Pang, Ya Luo, Dong Wei, Zhujie Cao, Xianmei Qi, Meiyue Song, Ying Liu, Zhaoguo Li, Jin Zhang, Baicun Li, Jingyu Chen, Jingyu Chen, Jing Wang, Chen Wang   +13 more
doaj   +1 more source

Silicosis [PDF]

Anales del Sistema Sanitario de Navarra, 2005
Silicosis, which acquired great significance during the period of increase in mining and construction, continues to be a pathology with a high morbidity and mortality within pneumoconiosis. Exposure to silica produces pathological, clinical and radiological alterations that together with compatible personal antecedents suggests its diagnosis in a ...
Abú- Shams, K., Fanlo, P., Lorente, M. P.   +2 more
openaire   +5 more sources

SIRT6-Mediated Deacetylation of ATF3 Promotes Silica-Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α. [PDF]

Adv Sci (Weinh)
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Cheng D, Bu W, Wang F, Jin Y, Liu R, Zhao R, Wang X, Jiang M, Shen J, Cheng X, Chen Z, Zhu L, Li J, Ge Z, Miao S, Xu H, Zhou X, Wang D, Zhao X.   +18 more
europepmc   +2 more sources

Global incidence, prevalence and disease burden of silicosis: 30 years’ overview and forecasted trends

BMC Public Health, 2023
Background Globally, silicosis accounts for 90% of all pneumoconiosis cases and is a serious public health issue. It is characterized by progressive inflammation and irreversible pulmonary fibrosis.
Xin Liu, Qingtao Jiang, Peihong Wu, Lei Han, P. Zhou   +4 more
semanticscholar   +1 more source

The exhaustion of lymphocytes is the main factor that decreases the sensitivity of QFT-GIT detection in silicosis

BMC Immunology, 2022
Background Tuberculosis infection is a major complication of silicosis, but there is no study on whether silicosis can affect the sensitivity of QuantiFERON-TB Gold In-Tube (QFT-GIT) assays.
Xin Yu, Li-Na Huang, Jun-Chi Xu, Yi-Yan Song, Hui Chen, Cui-Lin Shi, Pei-Jun Tang, Tao Tao, Ye-Han Zhu   +8 more
doaj   +1 more source

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

BMC Pulmonary Medicine, 2021
Background Silicosis is a progressive pneumoconiosis characterized by interstitial fibrosis following exposure to silica dust. The role of metabolic dysregulation in the pathogenesis of silicosis has not been investigated in detail.
Changjiang Xue, Na Wu, Yali Fan, Jing Ma, Qiao Ye   +4 more
doaj   +1 more source

Integrating RNA-Seq With GWAS Reveals a Novel SNP in Immune-Related HLA-DQB1 Gene Associated With Occupational Pulmonary Fibrosis Risk: A Multi-Stage Study

Frontiers in Immunology, 2022
ObjectiveTo evaluate the association between single-nucleotide polymorphisms (SNPs) in RNA-seq identified mRNAs and silicosis susceptibility.MethodsA comprehensive RNA-seq was performed to screen for differently expressed mRNAs in the peripheral blood ...
Yan Zhou, Yingyi Zhang, Rui Zhao, Zhounan Cheng, Minzhu Tang, Anni Qiu, Yang Dong, Yihua Lu, Yulong Lian, Xun Zhuang, Tian Tian, Wei Wang, Minjie Chu   +12 more
doaj   +1 more source