Results 51 to 60 of about 1,119,489 (299)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A combination of PD-1 and TIGIT immune checkpoint inhibitors elicits a strong anti-tumour response in mesothelioma

Journal of Experimental & Clinical Cancer Research
Background Finding effective and curative treatment for mesothelioma remains challenging. While the introduction of immunotherapy combinations using ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have offered hope for some patients, a large ...
Huaikai Shi, Ta-Kun Yu, Ben Johnson, Sakthi Priya Selvamani, Ling Zhuang, Kenneth Lee, Sonja Klebe, Samuel Smith, Kirby Wong, Kate Chen, Georgina Clark, Emma M. Rath, Holly Pearson, David Gallego Ortega, Anthony Linton, Steven Kao, Pablo Silveira, Yuen Yee Cheng   +17 more
doaj   +1 more source

A resolved analysis of cold dust and gas in the nearby edge-on spiral NGC 891 [PDF]

, 2014
We investigate the connection between dust and gas in the nearby edge-on spiral galaxy NGC 891. High resolution Herschel PACS and SPIRE 70, 100, 160, 250, 350, and 500 $\mu$m images are combined with JCMT SCUBA 850 $\mu$m observations to trace the far ...
Allaert, F., Baes, M., Bendo, G. J., Bianchi, S., Boquien, M., Boselli, A., Clements, D. L., Davies, J. I., De Looze, I., Fritz, J., Galametz, M., Gentile, G., Hughes, T. M., Madden, S. C., Parkin, T. J., Remy-Ruyer, A., Smith, M. W. L., Spinoglio, L., Verstappen, J., Viaene, S., Wilson, C. D.   +20 more
core   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Directional sensitivity of differential pressure sensors of gas velocity used in manual gravimetric measurements of dust emissions from stationary sources / Czułość kierunkowa różnicowo-ciśnieniowych czujników prędkości gazu stosowanych w manualnych pomiarach grawimetrycznych emisji zanieczyszczeń pyłowych ze źródeł stacjonarnych

Archives of Environmental Protection, 2015
Na potrzeby określania emisji zanieczyszczeń pyłowych do atmosfery z przemysłowych instalacji technologicznych często wykonywane są manualne pomiary rozkładu prędkości gazu w kanałach instalacji gazów odlotowych przy pomocy układów z różnicowo ...
Szulikowski Jerzy, Kateusz Przemysław
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Thermal Comfort and Energy Use with Local Heaters

Energies, 2020
This paper presents the investigation of a local heating system consisting of three heating mats incorporated within a sedentary workplace. Thermal comfort and individual power settings for the heating mats were studied in experiments with 41 human ...
Jan Kaczmarczyk, Joanna Ferdyn-Grygierek
doaj   +1 more source

Management from the Perspective of Islam [PDF]

پژوهش نامه معارف قرآنی, 2011
Islamic management is one of the necessities of an Islamic society. Therefore, any Islamic society requires a management system which is in line with Islamic patterns and is at the service of the Islamic society.
abbas azizi mehman dust, saeed sehat
doaj   +1 more source

Basic characteristics of mine dust suppression foam and the quantitative evaluation method of its performance

Meitan xuebao, 2023
The priority direction of mine dust control is to suppress dust generation and flying at the source. Foam, a gas-liquid two-phase medium, has some unique advantages of large dust covering area, strong adhesion ability and fast wetting of dust.
Hetang WANG, Qi ZHANG, Deming WANG, Xingcheng LI, Chaohang XU   +4 more
doaj   +1 more source

Dusty Nuclear Disks and Filaments in Early Type Galaxies [PDF]

, 2001
We examine the dust properties of a nearby distance-limited sample of early type galaxies using the WFPC2 of the Hubble Space Telescope. Dust is detected in 29 out of 67 galaxies (43%), including 12 with small nuclear dusty disks. In a separate sample of
A. Rest, Bennett S. M., Bettoni D., Buson L. M., F. C. van den Bosch, Faber S. M., Forbes D. A., Garcia A. M., Goudfrooij P., Goudfrooij P., H. C. Ford, H. D. Tran, J. Davies, Kannappan S. J., Kollatschny W., Kormendy J., Merluzzi P., Sadler E. M., Veron-Cetty M.-P., W. Jaffe, Z. Tsvetanov   +20 more
core   +2 more sources