Results 71 to 80 of about 1,119,489 (299)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Freshly Formed Dust in the Cassiopeia A Supernova Remnant as Revealed by the Spitzer Space Telescope [PDF]

, 2007
We performed Spitzer Infrared Spectrograph mapping observations covering nearly the entire extent of the Cassiopeia A supernova remnant (SNR), producing mid-infrared (5.5-35 micron) spectra every 5-10".
A. Tappe, Chini R., DeLaney T., H. Gomez, Henning Th., J. A. Ennis, J. D. Smith, J. Rho, Kozasa T., L. Rudnick, Lagage P. O., Maiolino R., Perez-Rendon B., T. DeLaney, T. Kozasa, W. T. Reach   +15 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of heterogeneous nucleation condensation effect on the surface of respiratory coal dust and test of dust reduction test

Meitan xuebao
Surface wettability of coal dust particles is an important factor restricting the efficiency of wet dust removal. Heterogeneous nucleation condensation on the surface of coal dust particles is a means without any pollution, without considering the ...
Hanyi LIN, Liang YUAN, Bingyou JIANG, Yuqian ZHANG, Yifan WANG, Haoyu WANG   +5 more
doaj   +1 more source

Dust capture and long-lived density enhancements triggered by vortices in 2D protoplanetary disks [PDF]

, 2016
We study dust capture by vortices and its long-term consequences in global two-fluid inviscid disk simulations using a new polar grid code RoSSBi.
Lin, Douglas N. C., Mayer, Lucio, Surville, Clément   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characterization of explosion propagation of coal dust deposited by gas explosion convolutions in closed pipelines

Meitan xuebao
To explore the propagation characteristics of gas explosion-induced coal dust detonations in enclosed pipelines, a custom-developed experimental system was employed for gas explosions involving accumulated coal dust.
Bingyou JIANG, Han HONG, Mingqing SU, Kunlun LU, Binghui YANG, Peilong WANG, Dawei DING   +6 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

International Journal of Coal Science & Technology
In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface, an experimental platform for forced ventilation and dust removal was built based on the similar principles.
Haotian Zheng, Bingyou Jiang, Haoyu Wang, Yuannan Zheng   +3 more
doaj   +1 more source