Results 41 to 50 of about 1,028,846 (258)
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan+10 more
wiley +1 more source
The emission by dust and stars of nearby galaxies in the Herschel KINGFISH survey [PDF]
Using new far-infrared imaging from the Herschel Space Observatory with ancillary data from ultraviolet (UV) to submillimeter wavelengths, we estimate the total emission from dust and stars of 62 nearby galaxies in the KINGFISH survey in a way that is as
Appleton, Philip+31 more
core +5 more sources
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
When you leave your home country, usually, you do not miss the country itself but the sense of belonging that being from somewhere grants you. Every immigrant knows intimately this particular yearning — even if you would not necessarily return to your “origin galaxy” you cannot help imagining what things could have been had certain circumstances had ...
openaire +3 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Sudan: eating dust and returning to dust [PDF]
In the early morning we drive out of the city. An asphalt road stretches like an endless ribbon, southwards into the desert. The wind is blowing, dust is seeping through every crack and cranny, entering the car but also my eyes, mouth, and ears. The area resembles a moon landscape: sand, rocks, and more sand. After an hour's drive we turn off the road
openaire +3 more sources
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma+9 more
wiley +1 more source
Magneto-thermal condensation modes including the effects of charged dust particles [PDF]
We study thermal instability in a magnetized and partially ionized plasma with charged dust particles. Our linear analysis shows that the growth rate of the unstable modes in the presence of dust particles strongly depends on the ratio of the cooling ...
Dib, Sami, Shadmehri, Mohsen
core +2 more sources