Results 71 to 80 of about 613,379 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Charge control experiments on a CH-53E helicopter in a dusty environment [PDF]

Charge control tests were carried out on a ground based, Marine Corps helicopter to determine if control of the electric fields acting on the engine exhaust gases could be used to reduce the electrification of the helicopter when it operated in a dusty ...
Hunyady, S. J., Jones, J. J., Moore, C. B.   +2 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Research on automatic dust mass concentration detection device based on membrane weighing method

Meitan xuebao
The traditional filter weighing method has a cumbersome operation process, a long detection cycle, and a low degree of automation. Although it has high accuracy, it cannot meet the needs of real-time detection of dust concentration.
Qinghua CHEN, Zengsheng XU, Xiaorun WANG, Bingyou JIANG, Mingyun TANG, Zuxiang HU, Jinwei QIU, Liang ZHOU   +7 more
doaj   +1 more source

Dust from Mars-Analog Plains (Iceland): Physico-Compositional Properties as a Function of Grain-Size Fraction [PDF]

Dust is a key component of the geological and climatic systems of Earth and Mars. On Mars, dust is ubiquitous. It coats rocks and soils, and, in the atmosphere, it interacts strongly with solar and thermal radiation.
Bedford, C., Champion, E., Ewing, R. C., Harrington, A. D., Horgan, B., Lapotre, M., Marcantonio, F., Mason, K., Nachon, Marion, Rampe, E. B., Romero, L., Schimmenti, D., Sinha, P., Thorpe, M. T., Tice, M.   +14 more
core   +1 more source

Factors Associated with Respiratory Complaints on Spinning Labor in PT. Lotus Indah Textile [PDF]

, 2012
The main contaminant of cotton dust is generated during the spinning process in PT. Lotus Indah Textile, Surabaya so that the workforce has the risk of occupational diseases, especially respiratory diseases.
Paskarini, I. (Indriati), Prasetya, S. (Sapta)   +1 more
core  

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Preparation and performance characterization of a molasses-based composite inhibitor for coal spontaneous combustion in steeply inclined goafs

Case Studies in Thermal Engineering
Coal spontaneous combustion (CSC) in goafs is a serious hazard to underground mine safety. Traditional inhibitors usually have weak bonding strength and high fluidity.
Mulati Jueraiti, Jianguo Liu, Minglei Lin, Longzhe Jin, Jie Yu, Tianyue Wang, Tuojiang Liu, Haosheng Wu, Rongyu Tian, Yao Ding, Hong Gao   +10 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Pollution Across Chinese Provinces [PDF]

We revisit the environmental Kuznets curve (EKC) hypothesis using 1987-1995 data for Chinese provinces. A comparison of off-sample (1996-2004) predictions to actual emissions indicates that more stringent rules are still needed to fight industrial (waste
Catherine Yap Co, Fanying Kong, Shuanglin Lin   +2 more
core   +1 more source