Results 51 to 60 of about 613,379 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Actively carrying out prevention and control of occupational injuries, and promoting comprehensive protection of workers' health

环境与职业医学
During the career life cycle, workers may face various health problems such as occupational injuries, occupational diseases, and work-related diseases.
Xiaojun ZHU, Yishuo GU, Jingguang FAN
doaj   +1 more source

B-mode Detection with an Extended Planck Mission

, 2009
The Planck satellite has a nominal mission lifetime of 14 months allowing two complete surveys of the sky. Here we investigate the potential of an extended Planck mission of four sky surveys to constrain primordial B-mode anisotropies in the presence of ...
, A. Kogut ., A. Pontzen, A.D. Linde, A.R. Liddle, B.P. Crill ., C.E. North ., C.L. Reichardt ., CMBPol Study Team collaboration, D.H. Lyth, G Efstathiou, G. Efstathiou, H.K. Eriksen, J. Bock ., K.M. Gorski ., L. McAllister, M. Cruz, M. Zaldarriaga ., M.D. Seiffert ., R. Kallosh, S Gratton, The Planck collaboration, V. Mukhanov, WMAP collaboration, WMAP collaboration, WMAP collaboration, WMAP collaboration   +26 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determination of 27 volatile organic compounds in exhaled breath by thermal desorption-gas chromatography-mass spectrometry

环境与职业医学
BackgroundVolatile organic compounds (VOCs) in exhaled breath are closely associated with respiratory diseases and are linked to various metabolic reactions in the human body.
Rui GAO, Fangda PENG, Yazhen HE, Jie FENG, Wubin LIU, Lijia YU, Qingsong CHEN, Chunguang DING   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characteristics and influencing factors of occupational injuries among workers in a cable manufacturing enterprise

环境与职业医学
BackgroundWorkers in the cable manufacturing industry are exposed to high-speed machinery and equipment for a long time, coupled with heavy workload, which poses significant risks to their physical health.
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Dust accretion and destruction in galaxy groups and clusters [PDF]

, 2010
We examine the dust distribution around a sample of 70,000 low redshift galaxy groups and clusters derived from the Sloan Digital Sky Survey. By correlating spectroscopically identified background quasars with the galaxy groups we obtain the relative ...
Adelman-McCarthy, Annis, Bahcall, Bai, Balogh, Balogh, Balogh, Bogart, Bovy, Boyle, Bregman, Calzetti, Chelouche, Crowl, Dai, Domainko, Draine, Draine, Eke, Finlator, Gerke, Gómez, Heckman, Holwerda, Hopkins, Kay, Lewis, Li, Mathis, McGee, McGee, McNamara, Michael L. Balogh, Montier, Muller, Ménard, O'Donnell, Parker, Pasquali, Pei, Pfrommer, Prevot, Reiprich, Richards, Romani, Rykoff, Schlegel, Schneider, Sean L. McGee, Sheldon, Sheldon, Shen, Spergel, Stickel, Tremonti, Tucker, Vikhlinin, Weingartner, Weinmann, Wilman, Wise, Yang, Yang, Zackrisson, Zibetti, Zwicky   +65 more
core   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source