Results 51 to 60 of about 9,638,357 (251)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Characteristics and influencing factors of occupational injuries among workers in a cable manufacturing enterprise

环境与职业医学
BackgroundWorkers in the cable manufacturing industry are exposed to high-speed machinery and equipment for a long time, coupled with heavy workload, which poses significant risks to their physical health.
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Relationship between occupational stress and occupational injury of workers in a cable manufacturing enterprise by decision tree model

环境与职业医学
BackgroundSocial psychological factors have emerged as a key area of research in occupational injury prevention. Occupational stress, a significant component of social psychology, has garnered widespread attention due to its potential impact on ...
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Screening for the Interaction of Diabetes Mellitus and Other Factors in Tuberculosis

Iranian Journal of Public Health, 2019
No Abstract No Abstract No ...
Min MU, Jing WU, Jian-Hua WANG, Xin-Rong TAO, Dong HU, Kai LIU, Ke-Hong FANG, Song XUE, Jie SHANG   +8 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A combined transient hygrothermal and population model of house dust mites in beds [PDF]

, 2001
This paper describes a current multidisciplinary U.K. funded research project aimed at developing a hygrothermal model of house dust mite response to environmental conditions.
Leung, B., Horwood, JA, Pretlove, S.E.C., Cox, P., Baker, N, Baker, N., Ridley, I., Oreszczyn, T., Ridley, I, Leung, B, Thomson, D, Crowther, D, Oreszczyn, T, Crowther, D., Cox, P, Thomson, D., Horwood, J A., Pretlove, SEC   +17 more
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Epidemiological trends of lung cancer attributed to residential radon exposure at global, regional, and national level: a trend analysis study from 1990 to 2021

Frontiers in Public Health
BackgroundLung cancer (LC) remains a leading cause of cancer-related mortality globally, with radon identified as the second major risk factor. This study aimed to analyze the global, regional, and national burden of LC attributed to residential radon ...
Qiang Xiong, Qiang Xiong, Zhen Zhang, Zhen Zhang, Jianliang Peng, Jianliang Peng, Jing Liang, Jing Liang, Dexing Lian, Dexing Lian, Xipeng Zhao, Xipeng Zhao, Lulu Wang, Lulu Wang, Tiangxiang Lu, Tiangxiang Lu, Yuwen Li, Yuwen Li   +17 more
doaj   +1 more source