Results 41 to 50 of about 613,379 (301)

Current situation, impact, and suggestions of practicing exemption from administrative penalty in occupational health work

open access: yes环境与职业医学
After the revision of the Law on Administrative Penalty, in order to optimize business environment and promote economic development, all localities have vigorously promoted inclusive and prudential supervision and flexible law enforcement, and the ...
Jiaqi WU, Jinyang JIA
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Multistage cooling system for temperature reduction of the working face in deep coal mines: A technical-economic evaluation

open access: yesCase Studies in Thermal Engineering, 2023
Workers in deep coal mines are often exposed to hyperthermal conditions, which is a health and safety hazard. Although many novel approaches have been proposed in recent years, air distribution optimization combined with thermal analysis based on ...
Tianyang Wang   +8 more
doaj   +1 more source

Laboratory Procedure for Measuring the Effectiveness of Dust Control Palliatives [PDF]

open access: yes, 2017
Creation of fugitive dust on unpaved roads results in the loss of up to 25 mm (one inch) of surface aggregate annually (FHWA, 1998). On these roads, shearing forces created by vehicles dislodge the fine aggregate fraction (silt and clay) that binds the ...
Barnes, David, Connor, Billy
core  

The color excess of quasars with intervening DLA systems- Analysis of the SDSS data release five

open access: yes, 2007
We analyzed the spectroscopic and photometric database of the 5th data release of the Sloan Digital Sky Survey (SDSS) to search for evidence of the quasar reddening produced by dust embedded in intervening damped Ly alpha (DLA) systems.
A. M. Wolfe   +69 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers

open access: yesToxics
Silicosis is an irreversible and progressive pulmonary fibrotic disease caused by the long-term inhalation of silica dust. The precise molecular mechanisms underlying the disease remain incompletely understood, and effective early diagnostic biomarkers ...
Jia Wang   +4 more
doaj   +1 more source

Use of Extreme Vertices Method for Analysis of How Proportional Composition Affects Component Interactions and Product Distribution during Hydrothermal Treatment

open access: yesBioResources, 2016
The interaction among three biomass components (hemicellulose, cellulose, and lignin) in an autoclave was studied based on the extreme vertices of a constrained region that had a significant effect on the distribution and characteristics of the products.
Ying Gao   +7 more
doaj   +1 more source

Study of the convection heat transfer law and temperature prediction of the duct in high-temperature tunnels

open access: yesCase Studies in Thermal Engineering, 2022
During the construction of tunnels subjected to high temperatures (here called high-temperature tunnels), ventilation cooling is an essential requirement. A high-temperature section of a construction tunnel on the Sichuan-Tibet Railway was used as a test
Guoliang Zhang   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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