Results 31 to 40 of about 9,638,357 (251)
环境与职业医学BackgroundLight gradient boosting machine (LightGBM) has become a popular choice in prediction models due to its high efficiency and speed. However, the "black box" issues in machine learning models lead to poor model interpretability.
Youhua MO +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Dust Control Handbook for Industrial Minerals Mining and Processing: Second Edition [2019] [PDF]
"This handbook was written by a task force of safety and health specialists, industrial hygienists, and engineers to provide information on proven and effective control technologies that lower workers' dust exposures during all stages of mineral ...
core +1 more source
Geochemistry and risk assessment of street dust in Luanda, Angola, a tropical urban environment [PDF]
, 2005 A total of 92 samples of street dust were collected in Luanda, Angola, were sieved below 100 μm, and analysed by ICP-MS for 35 elements after an aqua-regia digestion.
Miguel García, Eduardo de +1 more
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
环境与职业医学After the revision of the Law on Administrative Penalty, in order to optimize business environment and promote economic development, all localities have vigorously promoted inclusive and prudential supervision and flexible law enforcement, and the ...
Jiaqi WU, Jinyang JIA
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Applied Sciences, 2023 For the dust control of barren mine soils, protein and polysaccharide biopolymers have recently shown potential as environmentally friendly alternatives to conventional dust suppressants (e.g., salt brines or petroleum-based products).
Johannes L. Sieger +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ToxicsSilicosis is an irreversible and progressive pulmonary fibrotic disease caused by the long-term inhalation of silica dust. The precise molecular mechanisms underlying the disease remain incompletely understood, and effective early diagnostic biomarkers ...
Jia Wang +4 more
doaj +1 more source