Results 31 to 40 of about 613,379 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

International Journal of Coal Science & Technology
In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface, an experimental platform for forced ventilation and dust removal was built based on the similar principles.
Haotian Zheng, Bingyou Jiang, Haoyu Wang, Yuannan Zheng   +3 more
doaj   +1 more source

Performance of N95 elastomeric respirators in high humidity and high coal dust concentration environment

International Journal of Mining Science and Technology, 2022
High humidity and high dust concentration in deep coal mines may severely challenge the performance of respirators worn by coal miners. This paper aims at quantitatively evaluating the respirators used in deep coal mines and providing scientific guidance
Jintuo Zhu, Xinjian He, Liang Wang, Xiaoxue Liao, Guangping Teng, Pengli Jing   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Exploration of predicting occupational injury severity based on LightGBM model and model interpretability method

环境与职业医学
BackgroundLight gradient boosting machine (LightGBM) has become a popular choice in prediction models due to its high efficiency and speed. However, the "black box" issues in machine learning models lead to poor model interpretability.
Youhua MO, Peng ZHANG, YiShuo GU, Xiaojun ZHU, Jingguang FAN   +4 more
doaj   +1 more source

Prediction and Sensitivity Analysis of CO2 Capture by Amine Solvent Scrubbing Technique Based on BP Neural Network

Frontiers in Bioengineering and Biotechnology, 2022
With the rapid development of artificial intelligence, bionic algorithm has been gradually applied in various fields, and neural network has become an important and hot issue in the field of scientific research and engineering in recent years.
Jiangtao Fu, Jiangtao Fu, Jiangtao Fu, Jiangtao Fu, Yufeng Chang, Yufeng Chang, Bijie Huang, Bijie Huang   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Glycogen metabolism reprogramming promotes inflammation in coal dust-exposed lung

Ecotoxicology and Environmental Safety, 2022
Long-term coal dust exposure triggers complex inflammatory processes in the coal workers’ pneumoconiosis (CWP) lungs. The progress of the inflammation is reported to be affected by disordered cell metabolism.
Wenyang Wang, Min Mu, Yuanjie Zou, Songsong Deng, Yuting Lu, Qinglong Li, Zeyu Li, Huihui Tao, Yun Wang, Xinrong Tao   +9 more
doaj   +1 more source

Effect of ecological restoration programs on dust concentrations in the North China Plain: a case study [PDF]

, 2018
In recent decades, the Chinese government has made a great effort in initiating large-scale ecological restoration programs (ERPs) to reduce the dust concentrations in China, especially for dust storm episodes.
An, Zhisheng, Cao, Junji, Feng, Tian, Li, Guohui, Long, Xin, Tie, Xuexi, Xing, Li, Zhao, Shuyu   +7 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source