Results 101 to 110 of about 574,820 (241)

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

Forming of dust at destruction of layer by cutting tools of mining machines

, 2010
In work the question of analytical description of forming of dust is first considered at destruction of coal layers by cutting tools of cleansing combines and factors, influencing on the volume of the formed dust, are certain.В работе впервые рассмотрен ...
Бойко, Н.Г., Boyko, N., Бойко, Д.Е., Boyko, D.   +3 more
core  

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Dust destruction in the transition region between stellar wind and interstellar medium

, 1993
Simple theoretical considerations about three dust destruction mechanisms in shock fronts (thermal evaporation, destruction by sputtering due to gas-grain collisions and destruction by grain-grain collisions) are applied to the terminal shock between the
Dominik, C., Sedlmayr, E., Woitke, P.
core   +1 more source

On the dust abundance gradients in late-type galaxies - I. Effects of destruction and growth of dust in the interstellar medium

, 2012
We present basic theoretical constraints on the effects of destruction by supernovae (SNe) and growth of dust grains in the interstellar medium (ISM) on the radial distribution of dust in late-type galaxies.
Andersen, Anja C., Mattsson, Lars Mattias, Munkhammar, J.D., Munkhammar, Joakim D.,, Mattsson, Lars,, Andersen, Anja C.,   +5 more
core   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Missing dust of super-early galaxies

Astronomy & Astrophysics
Context. A subset of very young super-early galaxies at z ≳ 10, often called blue monsters, shows extremely blue UV continua and faint far-IR emission. This might imply much less dust than expected from standard enrichment scenarios. Aims.
Martínez-González Sergio, Jiménez Santiago, Muñoz-Tuñón Casiana   +2 more
doaj   +1 more source

Supernovae within Pre-existing Wind-blown Bubbles: Dust Injection versus Ambient Dust Destruction

, 2019
By means of 3D hydrodynamical simulations, we evaluate here the impact that supernova (SN) explosions occurring within wind-driven bubbles have on the survival or destruction of dust grains.
Martinez-Gonzalez S., Ferrara A., Palous J., Wunsch R., Tenorio-Tagle G., Silich S.   +5 more
core   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

Lab‐Scale Fabrication Process Selection for Soft Robotics: Benchmarking, Tradeoffs, and Guidelines for Formative Manufacturing of Soft Silicone Components

Advanced Intelligent Systems, EarlyView.
Fabrication shapes soft robot performance, but benchmarking data and selection guidelines remain scarce. We fabricate silicone actuators using two molding techniques and three mold types, characterizing them with cycle testing, microscopy, profilometry, and 3D imaging. Applying our lab‐scale, soft robotics‐specific fabrication evaluation criteria shows
Charlotte M. Folinus, Daniel Massimino, Cat Arase, Kaitlyn P. Becker   +3 more
wiley   +1 more source