Results 131 to 140 of about 184,359 (287)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Tracing the History of Obscured Star Formation with the SIMBA Cosmological Galaxy Evolution Simulation

The Astrophysical Journal
We explore the cosmic evolution of the fraction of dust-obscured star formation predicted by the simba cosmological hydrodynamic simulations featuring an on-the-fly model for dust formation, evolution, and destruction.
Dhruv T. Zimmerman, Desika Narayanan, Katherine E. Whitaker, Romeel Davé   +3 more
doaj   +1 more source

Evolution of dust extinction curves in galaxy simulation

, 2017
To understand the evolution of extinction curve, we calculate the dust evolution in a galaxy using smoothed particle hydrodynamics simulations incorporating stellar dust production, dust destruction in supernova shocks, grain growth by accretion and ...
Aoyama, Shohei, Hirashita, Hiroyuki, Hou, Kuan-Chou, Nagamine, Kentaro, Shimizu, Ikkoh   +4 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

On the (in)variance of the dust-to-metals ratio in galaxies

, 2014
Recent works have demonstrated a surprisingly small variation of the dust-to-metals ratio in different environments and a correlation between dust extinction and the density of stars.
Andersen, Anja C., De Cia, Annalisa, Mattsson, Lars, Zafar, Tayyaba   +3 more
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

Missing dust of super-early galaxies

Astronomy & Astrophysics
Context. A subset of very young super-early galaxies at z ≳ 10, often called blue monsters, shows extremely blue UV continua and faint far-IR emission. This might imply much less dust than expected from standard enrichment scenarios. Aims.
Martínez-González Sergio, Jiménez Santiago, Muñoz-Tuñón Casiana   +2 more
doaj   +1 more source

Life Cycle of Dust in the Magellanic Clouds and the Milky Way

, 2014
To a great extent, our understanding of the life cycle of dust is based on the observational and theoretical studies of the Milky Way and the Magellanic Clouds, which will be the topic of this contribution. Over past years, a large volume of observations
Henning, Thomas, Zhukovska, Svitlana
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source