Results 21 to 30 of about 14,680 (246)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Patterns in Dutch For Ten-Letter Words [PDF]

, 2001
In Near-Alternating Vowels and Consonants in the August 2000 issue of Word Ways, A. Ross Eckler exhibited English words for all but three of the 178 distinct ways one can assign consonants and vowels to ten-letter words so that there are no more than ...
Corstius, Hugo Brandt
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Frisian substrate versus internal change in Western Dutch

Filologia Germanica
One of the main features which distinguish the dialects of western Dutch from their eastern neighbours, is the presence of an unrounded short vowel i or e in a number of words where the standard language displays rounded u, such as western brig(ge ...
Michiel De Vaan
doaj   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

The role of word recognition factors and lexical stress in the distribution of consonants in Spanish, English and Dutch

Journal of Linguistics, 2022
The distribution of labials and coronals within Spanish CVCVCV words and English and Dutch CVCVC words has been studied from a functional perspective and in fine detail. We argue that word recognition is key in the explanation of the results; as a word is pronounced, an increasing number of word candidates is eliminated, and consequently the beginning ...
openaire   +1 more source

Фонетична транскрипція та відбір дикторів при зіставному аналізі германських та слов’янських мов (Phonetische transkription und sprecherauswahl bei der vergleichenden analyse von germanischen und slawischen sprachen) [PDF]

, 2016
Стаття присвячена проблемі порівняльного аналізу реалізації голосних і приголосних в сучасній німецькій, англійській, нідерландській, українській, російській та польській мовах.
Рудківський, О. (O. Rudkivskyi)
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Subphonemic and suballophonic consonant variation : the role of the phoneme inventory [PDF]

, 2013
Consonants exhibit more variation in their phonetic realization than is typically acknowledged, but that variation is linguistically constrained. Acoustic analysis of both read and spontaneous speech reveals that consonants are not necessarily realized ...
Lavoie, Lisa M.
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source