Results 131 to 140 of about 2,096,377 (330)
Scientia Iuris, 2009 Contracts are the main instrument of circulation of wealth as well as of the most diverse interests. The problem arises if it does not achieve its purposes and frustrate the interests of those involved, who may decide for the breach of the duty, the core
Cláudio José Franzolin
doaj
Smuggling and import duties in Myanmar [PDF]
This paper examines the effects of import duties on smuggling in Myanmar. Following Fisman and Wei (2004), the reporting discrepancies between Myanmar’s imports records and corresponding exports recorded by trading partners are regarded as indicative ...
Kubo, Koji, Nu Nu Lwin
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lingue e Linguaggi, 2016 – The relation between language and law is very complex and profound, and it includes the ‘intrinsic’ aspect and the ‘extrinsic’ one. The first deals with the theory of juridical interpretation, which is the clearest example of contact between the ...
Giovanni Poggeschi
doaj
The Claims of Animals and the Needs of Strangers: Two Cases of Imperfect Right [PDF]
, 2018 This paper argues for a conception of the natural rights of non-human animals grounded in Kant’s explanation of the foundation of human rights. The rights in question are rights that are in the first instance held against humanity collectively speaking ...
Korsgaard, Christine M.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
GATT and the new protectionism [PDF]
The Uruguay Round of the General Agreement on Tariffs and Trade (GATT) is the first agreement of its kind that reduces or eliminates tariffs on many goods and addresses issues related to intellectual property rights, trade in services and agricultural ...
David M. Gould, William C. Gruben
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Paternalism and Duties to Self [PDF]
, 2018 Here I pursue two main aims: (1) to articulate and defend a Kantian conception of duties to self, and (2) to explore the ramifications of such duties for the moral justification of paternalism.
Cholbi, Michael
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source