Results 111 to 120 of about 1,712,755 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MORAL DUTIES TOWARDS FUTURE GENERATIONS: AN UBUNTU APPRAISAL
Glocalism: Journal of Culture, Politics and InnovationWhat is the worth of future people, and do we owe moral duties to such individuals? Based on African ethics, i.e., the “Ubuntu” ethic, I seek not only to show the worth of people not yet born but also to consider duties of the poor and the state towards
Rudolph Nyamudo
doaj +1 more source
What is the Effect of U.S. Antidumping Duties on Imports? Some Evidence from the Sunset Review Process [PDF]
The voluminous literature on the U.S. antidumping laws has a curious lacuna. There is little in this literature about the effects of antidumping duties on the volume of subject imports. One reason this key question has not frequently been investigated is
William W. Nye
core
Aristotle on the Normative Value of Friendship Duties [PDF]
, 2018 In this article, I present an interpretation of Aristotle’s thought regarding the normative value of friendship duties.The argument is divided in VII sections.
Nascimento, Daniel Simão
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Presidential Inability: Hearing Before the Special Subcommittee on Study of Presidential Inability of the Committee on the Judiciary, House of Representatives, 85th Congress [PDF]
, 1957 Text of proposed legislation, testimony, and documents relating to situations in which the President is unable to discharge the powers and duties of his office.https://ir.lawnet.fordham.edu/twentyfifth_amendment_congressional_materials/1003/thumbnail ...
Special Subcommittee To Study Presidential Inability
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Factors Leading to a Lack of Leisure Time in High School Students in Croatia
Acta Paedagogica VilnensiaFor a person’s overall health, it is important to establish a proper connection between work and leisure. This paper shows the results of theoretical and empirical research on factors leading to a lack of leisure time in high school students.
Martina Lončar +2 more
doaj +1 more source