Results 91 to 100 of about 307,058 (315)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Southeast U.S.A. Shrimp Industry: Issues Related to Trade and Antidumping Duties
On December 31, 2003 a coalition representing Southeast U.S.A. shrimp harvesters and processors filed a petition with the U.S. International Trade Administration and the U.S. International Trade Commission seeking relief in the form of antidumping duties
Poudel, Pawan, Keithly, Walter R., Jr.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Anti-circumvention duties after the Screwdriver Panel Report
, 1993 Screwdriver-plants allowed foreign firms to circumvent anti-dumping duties. This move resulted in the introduction of anticircumvention duties in the EEC and the United States.First, the EEC approach is analysed.
Torremans, Paul
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Проблеми теорії та методології бухгалтерського обліку, контролю і аналізуThe article examines the trends in the development of tax systems of the EU member states. The article focuses on the dynamics of tax revenues to the common budget of the European Union.
D.O. Grytsyshen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Frankenstein: Children, Duties, and the (In)Justice of Rights
HumanitiesThis essay explores Mary Shelley’s contribution to the political philosophy of children’s rights and its connection to duties-based justice by establishing a dialogue between Frankenstein and The Rights of Infants (1797).
Enit Karafili Steiner
doaj +1 more source