Results 171 to 180 of about 2,567,418 (399)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

DLC COATED RING PACK FOR HEAVY DUTY DIESEL ENGINES [PDF]

open access: gold, 2017
Rafael Bruno   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Nietzsche o Kantovi: Královecké číňanství?

open access: yesFilosofický časopis
To what extent is Nietzsche’s critique of Kant empty rhetoric, and to what extent is it a substantive argument to be taken seriously? Within the broad Nietzschean- Kantian polemics, the study is concerned with the ethical domain. It starts from the title
Sikora, Ondřej
doaj   +1 more source

Comparing SARS-CoV-2 infections in the US Military Health System and national data: opportunities for future pandemic surveillance. [PDF]

open access: yesFront Public Health
Craig-Kuhn MC   +10 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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