Results 61 to 70 of about 2,567,418 (399)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
BASIC MORAL STANDARDS IN ETIC SYSTEM OF I. KANT
Дискурс, 2017 The article reviews main items of I. Kant ethical system based on I. Kant work “Critique of Pure Reason”, “Groundwork of the Metaphysics of Morals”, “Prolegomena to Any Future Metaphysics”. The article analyzes the main issues of I. Kant philosophy: will
A. M. Sklyarovа
doaj +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Regulation of the Labour relations in the first period of the Great Patriotic War
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2013 The questions of the changing standards in the USSR Labour Code during the War in 1922 are examined in the article. The more regular using of the labour duty, mobilization of the citizens into industrial and building works, the Legalization of overtime ...
Pishchulina Svetlana Yurievna
doaj +1 more source
An In-Depth Examination of the Implementation of the Disability Equality Duty in England: Report for the Office for Disability Issues [PDF]
, 2008 This seven-month study examined the implementation of the Disability Equality Duty (DED) in England. The DED, introduced through the Disability Discrimination Act 2005, applies to public authorities in England, Wales and Scotland.
Ferrie, Joanna +5 more
core
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Railcars From Canada: A Misapplication of the Countervailing Duty Law [PDF]
, 1983 This Note examines the countervailing duty law and how it was applied in Railcars. Part I discusses the MTA\u27s decision to award the subway car contract to Bombardier, Inc., a Canadian corporation.
Kirschner, Rhonda G.
core +1 more source
Cooperative Look-Ahead Control for Fuel-Efficient and Safe Heavy-Duty Vehicle Platooning [PDF]
IEEE Transactions on Control Systems Technology, 2015 The operation of groups of heavy-duty vehicles at a short inter-vehicular distance, known as platoon, allows one to lower the overall aerodynamic drag and, therefore, to reduce fuel consumption and greenhouse gas emissions. However, due to the large mass
Valerio Turri +2 more
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source