Results 171 to 180 of about 3,423 (190)

Erratum for the Research Article "DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia" by D. Campolungo <i>et al</i>.

Sci Adv
europepmc   +1 more source

N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4‐fused B‐ALL)

Genes, Chromosomes and Cancer, 2022
AbstractB‐lymphoblastic leukemia/lymphoma (B‐ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B‐ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis.
Bradford J. Siegele, Anat O. Stemmer‐Rachamimov, Henrik Lilljebjorn, Thoas Fioretos, Amanda C. Winters, Paola Dal Cin, Amy Treece, Alisa Gaskell, Valentina Nardi   +8 more
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DUX4 in Cells and Mice [PDF]

, 2008
By targeting each FSHD candidate gene to a doxycycline-inducible locus in murine C2 myoblasts, we have shown that DUX4 is uniquely toxic, that this toxicity is caused by sensitizing cells to oxidative stress, and that both Pax3 and Pax7 act as dominant inhibitors of the DUX4 phenotype.
Bosnakovski, Darko, Kyba, Michael
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DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor

American Journal of Surgical Pathology, 2017
The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized entity CIC-DUX4 fusion-positive round cell tumor. The diagnosis of CIC-DUX4 tumor can be suggested by light microscopic and immunohistochemical features, but currently, definitive diagnosis requires ancillary genetic testing such ...
Bradford, Siegele, Jon, Roberts, Jennifer O, Black, Erin, Rudzinski, Sara O, Vargas, Csaba, Galambos   +5 more
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Ultrastructure of CIC-DUX4 sarcoma: the first pathological report

Ultrastructural Pathology, 2020
CIC-DUX4 sarcoma (CDS) is a recently identified subtype of small round cell sarcoma. Morphologically, CDS partially resembles Ewing sarcoma (ES) and has been classified as "ES-like sarcoma"; however, detailed clinicopathologic and molecular genetic analyses have indicated that CDS is a new independent disease.
Hisashi, Tamada, Mikiko, Kobayashi, Kenji, Sano, Takeshi, Uehara, Yuki, Matsumoto, Ayako, Tateishi, Maki, Ohya, Munehisa, Kito, Kaoru, Aoki, Hiroyuki, Kanno   +9 more
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The role of DUX4 in herpesviral infection

2021
Herpesviren sind sehr verbreitete humane Pathogene, die eine Vielzahl von Erkrankungen wie z.B. Lippenherpes, Windpocken oder Mononukleose auslösen. Während die Infektionen in Menschen mit einem gesunden Immunsystem meist mild verlaufen, können sie für Neugeborene oder Immungeschwächte sogar lebensbedrohlich sein.
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Estrogen interferes with DUX4 nuclear import

2023
DUX4 (Double Homeobox Protein 4) pathogenic activity is developed through transcriptional function and is associated with its nuclear localization. Three monopartite nuclear localization signals (NLS) are present in DUX4, but their function has not been completely defined in myoblasts (Corona et al., 2013).
Giada Mele, Fabiola Moretti, Giancarlo Deidda, Patrizia Calandra, Emanuela Teveroni, Silvia Maiullari, Marco Crescenzi, Maria Luisa Casella   +7 more
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Ferroptosis as a treatment for CIC-DUX4 sarcoma

CIC-DUX4 sarcoma (CDS) is a rare, undifferentiated small round cell malignancy. CDS occurs due to a recurrent chromosomal translocation, fusing the transcriptional repressor Capicua (CIC) to DUX4, a developmental gene typically repressed in adult somatic cells.
Raleigh, Mariya, 0009-0006-0975-2286
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Relationship of DUX4 and target gene expression in FSHD myocytes

Human Mutation, 2021
Xiangduo Kong, Nam Viet Nguyen, Katherine Williams   +2 more
exaly  

Persistent Fibroadipogenic Progenitor Expansion Following Transient DUX4 Expression Provokes a Profibrotic State in a Mouse Model for FSHD

International Journal of Molecular Sciences, 2022
Darko Bosnakovski, Madison Douglas, Elizabeth T Ener   +2 more
exaly