Results 161 to 170 of about 3,790 (193)

Therapeutic Strategies Targeting DUX4 in FSHD [PDF]

Journal of Clinical Medicine, 2020
Facioscapulohumeral muscular dystrophy (FSHD) is a common muscle dystrophy typically affecting patients within their second decade. Patients initially exhibit asymmetric facial and humeral muscle damage, followed by lower body muscle involvement. FSHD is
Laura le Gall, Julie Dumonceaux, Virginie Mariot   +2 more
exaly   +8 more sources

N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4‐fused B‐ALL)

Genes Chromosomes and Cancer, 2022
B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass ...
Amanda C Winters, Henrik Lilljebjörn, Thoas Fioretos   +2 more
exaly   +4 more sources

Relationship of DUX4 and target gene expression in FSHD myocytes [PDF]

Human Mutation, 2021
Facioscapulohumeral dystrophy (FSHD) is associated with the upregulation of the DUX4 transcription factor and its target genes. However, low-frequency DUX4 upregulation in patient myocytes is difficult to detect and examining the relationship and ...
Katherine Williams, Kyoko Yokomori, Ali Mortazavi   +2 more
exaly   +2 more sources

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DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor

American Journal of Surgical Pathology, 2017
The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized entity CIC-DUX4 fusion-positive round cell tumor. The diagnosis of CIC-DUX4 tumor can be suggested by light microscopic and immunohistochemical features, but currently, definitive diagnosis requires ancillary genetic testing such ...
Bradford, Siegele, Jon, Roberts, Jennifer O, Black, Erin, Rudzinski, Sara O, Vargas, Csaba, Galambos   +5 more
openaire   +2 more sources

The role of DUX4 in herpesviral infection

2021
Herpesviren sind sehr verbreitete humane Pathogene, die eine Vielzahl von Erkrankungen wie z.B. Lippenherpes, Windpocken oder Mononukleose auslösen. Während die Infektionen in Menschen mit einem gesunden Immunsystem meist mild verlaufen, können sie für Neugeborene oder Immungeschwächte sogar lebensbedrohlich sein.
openaire   +1 more source

Dux4 expression in human cells.

We measured total transcription in cells by RNA-sequencing following forced expression of Dux4 for identification of novel Dux4-regulated gene products.   
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The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors

FEBS Letters, 2022
Scott Harper, Alberto Luis Rosa, Nizar Y Saad   +2 more
exaly  

Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer

Trends in Molecular Medicine, 2021
Anna Schwager, Yegor Vassetzky, Carla Dib   +2 more
exaly  

Ferroptosis as a treatment for CIC-DUX4 sarcoma

CIC-DUX4 sarcoma (CDS) is a rare, undifferentiated small round cell malignancy. CDS occurs due to a recurrent chromosomal translocation, fusing the transcriptional repressor Capicua (CIC) to DUX4, a developmental gene typically repressed in adult somatic cells.
Raleigh, Mariya, 0009-0006-0975-2286
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