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The role of DUX4 in herpesviral infection
2021Herpesviren sind sehr verbreitete humane Pathogene, die eine Vielzahl von Erkrankungen wie z.B. Lippenherpes, Windpocken oder Mononukleose auslösen. Während die Infektionen in Menschen mit einem gesunden Immunsystem meist mild verlaufen, können sie für Neugeborene oder Immungeschwächte sogar lebensbedrohlich sein.
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Estrogen interferes with DUX4 nuclear import
2023DUX4 (Double Homeobox Protein 4) pathogenic activity is developed through transcriptional function and is associated with its nuclear localization. Three monopartite nuclear localization signals (NLS) are present in DUX4, but their function has not been completely defined in myoblasts (Corona et al., 2013).
Giada Mele +7 more
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Relationship of DUX4 and target gene expression in FSHD myocytes
Human Mutation, 2021Katherine Williams +2 more
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Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer
Trends in Molecular Medicine, 2021Anna Schwager +2 more
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Ferroptosis as a treatment for CIC-DUX4 sarcoma
CIC-DUX4 sarcoma (CDS) is a rare, undifferentiated small round cell malignancy. CDS occurs due to a recurrent chromosomal translocation, fusing the transcriptional repressor Capicua (CIC) to DUX4, a developmental gene typically repressed in adult somatic cells.Raleigh, Mariya, 0009-0006-0975-2286
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RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy
Journal of Cachexia, Sarcopenia and Muscle, 2021Christophe Hourdé +2 more
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Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible Treatments
International Journal of Molecular Sciences, 2023Elisa Duranti +2 more
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The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors
FEBS Letters, 2022Scott Harper +2 more
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