Results 131 to 140 of about 2,593 (166)

Clinicopathologic correlates of Ewing (FET::ETS-rearranged) sarcoma and non-Ewing undifferentiated small round cell sarcomas across skeletal and extraskeletal sites. [PDF]

Front Oncol
Ali RH, Al-Otaibi HS, Abdulmoneim SAK, Mohammed EMA, Alsaber AR, Hassan A, Khalifa N, Ali AA, Ahmed AA, Bahzad S, Alenezi FG, AlNassar M, AlJassim A.   +12 more
europepmc   +1 more source

Mitochondrial Respiratory Chain Function is crucial for Muscle Toxicity in Facioscapulohumeral Muscular Dystrophy

Heher P, Pfeiffer-Vogl J, Ganassi M, Fulea R, McGuire L, Engquist EN, Tyszkiewicz M, Prueller J, Grillari J, Tasca G, Banerji CR, Zammit PS.   +11 more
europepmc   +1 more source

Primary ovarian CIC-rearranged sarcoma in a child: a rare case report and review of the literature. [PDF]

Front Med (Lausanne)
Ke L, Liu L, Wu Y, Sun Y, Wang Y, Xia J, Zhang W.   +6 more
europepmc   +1 more source

DUX4 protein partners in muscle cells are linked to DNA repair, transcription and DUX4 post-translational regulation

Slavin, Moriya, Claus, Clothilde, Bah, Karimatou, Zohar, Keren, Eliyahu, Tziona, Linial, Michal, Coppée, Frédérique, Kalisman, Nir   +7 more
openaire   +1 more source

Erratum for the Research Article "DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia" by D. Campolungo <i>et al</i>.

Sci Adv
europepmc   +1 more source

Therapeutic Strategies Targeting DUX4 in FSHD [PDF]

Journal of Clinical Medicine, 2020
Facioscapulohumeral muscular dystrophy (FSHD) is a common muscle dystrophy typically affecting patients within their second decade. Patients initially exhibit asymmetric facial and humeral muscle damage, followed by lower body muscle involvement. FSHD is associated with a derepression of DUX4 gene encoded by the D4Z4 macrosatellite located on the ...
Laura Le Gall, Julie Dumonceaux, Virginie Mariot   +2 more
exaly   +4 more sources

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N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4‐fused B‐ALL)

Genes, Chromosomes and Cancer, 2022
AbstractB‐lymphoblastic leukemia/lymphoma (B‐ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B‐ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis.
Bradford J. Siegele, Anat O. Stemmer‐Rachamimov, Henrik Lilljebjorn, Thoas Fioretos, Amanda C. Winters, Paola Dal Cin, Amy Treece, Alisa Gaskell, Valentina Nardi   +8 more
openaire   +2 more sources

DUX4 Immunohistochemistry Is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor

American Journal of Surgical Pathology, 2017
The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized entity CIC-DUX4 fusion-positive round cell tumor. The diagnosis of CIC-DUX4 tumor can be suggested by light microscopic and immunohistochemical features, but currently, definitive diagnosis requires ancillary genetic testing such ...
Bradford, Siegele, Jon, Roberts, Jennifer O, Black, Erin, Rudzinski, Sara O, Vargas, Csaba, Galambos   +5 more
openaire   +2 more sources

DUX4 in Cells and Mice [PDF]

, 2008
By targeting each FSHD candidate gene to a doxycycline-inducible locus in murine C2 myoblasts, we have shown that DUX4 is uniquely toxic, that this toxicity is caused by sensitizing cells to oxidative stress, and that both Pax3 and Pax7 act as dominant inhibitors of the DUX4 phenotype.
Bosnakovski, Darko, Kyba, Michael
openaire