Results 111 to 120 of about 3,423 (190)

DUX4 partnership [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Die Rolle von DUX4 während der herpesviralen Infektion

, 2021
Herpesviruses are common human pathogens with a high worldwide prevalence. They cause a variety of diseases for example cold sore, chicken pox or mononucleosis.
Walter, Stephanie
core  

DUX4 surexpression and silencing in a murine model [PDF]

, 2017
FSHD is a muscular dystrophy characterized by muscle atrophy. It is caused by mis-expression of DUX4 transcription factor in skeletal muscle cells. Potential therapeutic agents (AOs, siRNA) inhibiting DUX4 expression in muscles showed promising results ...
Legrand, Alexandre, Derenne, Aline, De Roeck, Estelle, Coppée, Frédérique, Tassin, Alexandra, Decleves, Anne-Emilie   +5 more
core  

Schematic of chromosome 4, D4Z4, and DUX4-expressing AAV vectors.

, 2015
A: A representation of the telomeric region of the chromosome 4 long arm (4q35). Drawing is not to scale. The 4q35 subtelomere harbors polymorphic, 3.3 kb D4Z4 repeat arrays, as well as other genes, some of which are indicated.
Jocelyn O. Eidahl (699964), Carlee R. Giesige (699966), Scott Q. Harper (699968), Nettie K. Pyne (699967), Susan M. Guckes (699965), Eugénie Ansseau (198885), Jacqueline S. Domire (699962), Lindsay M. Wallace (699963), Alexandra Belayew (113230)   +8 more
core   +1 more source

Mouse model to understand the role of Dux4 in FSHD [PDF]

, 2011
FSHD is an autosomal dominant disease that affects 1:20000 individuals. Mapping studies have associated the disease with a reduced number (1-10) of the D4Z4 macrosatellite repeats from the usual ~100.
Bosnakovski, Darko, Hartweck, Lynn M., Dandapat, Abhijit, Kyba, Michael, Lonetree, Cara-lin, Nash, Nardine, Lowe, Dawn, Baltgalvis, Kristen   +7 more
core  

RNA in situ hybridisaatio DUX4 transkriptin havainnoimiseksi DUX4-TetOn ihmisen alkion kantasoluissa ja ovarionäytteissä käyttäen RNAscope-tekniikkaa

Double homeobox 4 (DUX4) on transkriptiotekijä, jonka ekspressio on normaalisti hiljennetty somaattisissa soluissa, mutta jonka ekspressio aktivoituu varhaisessa alkiossa. Alkio käyttää maternaalisia transkriptejä ennen kuin sen oman genomin transkriptio
Narvanto, Jenni
core  

Sarcoma With CIC-DUX4 Gene Fusion

, 2017
Recent molecular advances have identified a novel sarcoma defined molecularly by oncogenic fusion of the genes CIC and DUX4 termed CIC-DUX4 sarcomas. The most common site of involvement was the trunk but some cases have been described in the head and ...
Allirot Camille, Durand Chantal, Delattre Olivier, Sartelet Hervé, Piolat Christian, Nika Eleni, Bobillier-Chaumont Severine, Plantaz Dominique, Anne Mc Leer-Florin, Saada-Sebag Geraldine, Perret Cécile, Bidaut Anne-Sophie, Pierron Gaelle   +12 more
core   +1 more source

Evaluation of new antisense oligomers targeting the DUX4 mRNA

, 2013
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common hereditary muscle disorders. Its molecular mechanism involves DNA hypomethylation and chromatin de-repression at the D4Z4 repeat array of chromosome 4q35.
Guckes, Susan M, Harper, Scott Q., Domire, Jacqueline S, Yip, Cassandre, Coppée, Frédérique, Ansseau, Eugénie, Laoudj-Chenivesse, Dalila, Belayew, Alexandra, Tassin, Alexandra, Wallace, Lindsay M, Wilton D., Steve, Vanderplanck, Céline   +11 more
core  

DUX4 wt Allele [PDF]

, 2020
openaire   +1 more source

A dedicated caller for DUX4 rearrangements from whole-genome sequencing data

BMC Medical Genomics
Rearrangements involving the DUX4 gene (DUX4-r) define a subtype of paediatric and adult acute lymphoblastic leukaemia (ALL) with a favourable outcome. Currently, there is no ‘standard of care’ diagnostic method for their confident identification.
Pascal Grobecker, Stefano Berri, John F. Peden, Kai-Jie Chow, Claire Fielding, Ivana Armogida, Helen Northen, David J. McBride, Peter J. Campbell, Jennifer Becq, Sarra L. Ryan, David R. Bentley, Christine J. Harrison, Anthony V. Moorman, Mark T. Ross, Martina Mijuskovic   +15 more
doaj   +1 more source