Results 101 to 110 of about 3,423 (190)
Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA
Cell Reports, 2018 Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia.
John K. Lee +9 more
openaire +3 more sources
DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression
, 2018 Thesis (Ph.D.)--University of Washington, 2018The DUX4 transcription factor is briefly expressed in the cleavage-stage embryo where it induces an early wave of zygotic gene transcription; whereas its mis-expression in skeletal muscle causes the muscular ...
Resnick, Rebecca May
core
Post-Translational Modifications of the DUX4 Protein Impact Toxic Function in FSHD Cell Models
, 2023 Objective: Facioscapulohumeral muscular dystrophy (FSHD) is caused by abnormal de-repression of the myotoxic transcription factor DUX4. Although the transcriptional targets of DUX4 are known, the regulation of DUX4 protein and the molecular consequences ...
Freitas, Michael A +13 more
core +1 more source
, 2013 (A) DUX4-bound regions show correlated activation levels in FSHD patient myotubes and in our DUX4-transduced myoblast experimental system. We show log2-activation levels in each system, counting RNA-seq reads within an arbitrary 1 kb of DUX4-bound ...
Zizhen Yao (48910) +9 more
core +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source
Interrogating Dux4 Mrna 3′ End Processing
, 2016 Double Homeobox 4, Dux4, is the leading candidate gene for Facioscapulohumeral Dystrophy (FSHD). FSHD is the third most common muscular dystrophy, and is characterized by progressive muscle weakness primarily in the upper body.
Peart, Natoya J
core
Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics
, 2016 Derepression of DUX4 in skeletal muscle has emerged as a likely cause of pathology in facioscapulohumeral muscular dystrophy (FSHD). Here we report on the use of antisense phosphorodiamidate morpholino oligonucleotides to suppress DUX4 expression and ...
Clayton, Nicholas P. +7 more
core +1 more source
DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers
eLifeCancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is ...
Jose Mario Bello Pineda +1 more
doaj +1 more source
Epigenetic regulation of DUX4: From embryogenesis to muscular degeneration
Current Opinion in Cell BiologyDUX4 is a transcription factor with a critical role in zygotic genome activation. It is expressed briefly in early embryogenesis and shut off for the rest of life. Inappropriate reactivation of DUX4 in adult muscle cells causes facioscapulohumeral dystrophy (FSHD), a muscular dystrophy affecting up to 1 in 8000, currently with no cure.
Leyi Li, Arnab Ray, Shifeng Xue
openaire +2 more sources