Results 101 to 110 of about 3,790 (193)

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

DUX4 partnership [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic

Molecular Therapy: Methods & Clinical Development
Facioscapulohumeral muscular dystrophy (FSHD) is the third most diagnosed muscular dystrophy. The disease is caused by genetic and epigenetic disruptions that result in misexpression of the germline transcription factor DUX4 in skeletal muscle, leading ...
Katelyn Daman, Jing Yan, Annabelle Biscans, Dimas Echeverria, Taisia Shmushkovich, Alexey Wolfson, Julia F. Alterman, Anastasia Khvorova, Charles P. Emerson, Jr.   +8 more
doaj   +1 more source

RNA in situ hybridisaatio DUX4 transkriptin havainnoimiseksi DUX4-TetOn ihmisen alkion kantasoluissa ja ovarionäytteissä käyttäen RNAscope-tekniikkaa

Double homeobox 4 (DUX4) on transkriptiotekijä, jonka ekspressio on normaalisti hiljennetty somaattisissa soluissa, mutta jonka ekspressio aktivoituu varhaisessa alkiossa. Alkio käyttää maternaalisia transkriptejä ennen kuin sen oman genomin transkriptio
Narvanto, Jenni
core  

Mouse model to understand the role of Dux4 in FSHD [PDF]

, 2011
FSHD is an autosomal dominant disease that affects 1:20000 individuals. Mapping studies have associated the disease with a reduced number (1-10) of the D4Z4 macrosatellite repeats from the usual ~100.
Bosnakovski, Darko, Hartweck, Lynn M., Dandapat, Abhijit, Kyba, Michael, Lonetree, Cara-lin, Nash, Nardine, Lowe, Dawn, Baltgalvis, Kristen   +7 more
core   +1 more source

A dedicated caller for DUX4 rearrangements from whole-genome sequencing data

BMC Medical Genomics
Rearrangements involving the DUX4 gene (DUX4-r) define a subtype of paediatric and adult acute lymphoblastic leukaemia (ALL) with a favourable outcome. Currently, there is no ‘standard of care’ diagnostic method for their confident identification.
Pascal Grobecker, Stefano Berri, John F. Peden, Kai-Jie Chow, Claire Fielding, Ivana Armogida, Helen Northen, David J. McBride, Peter J. Campbell, Jennifer Becq, Sarra L. Ryan, David R. Bentley, Christine J. Harrison, Anthony V. Moorman, Mark T. Ross, Martina Mijuskovic   +15 more
doaj   +1 more source

DUX4 wt Allele [PDF]

, 2020
openaire   +1 more source

Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy

The Journal of Clinical Investigation
Facioscapulohumeral muscular dystrophy (FSHD) is a genetic muscle disease caused by ectopic expression of the toxic protein DUX4, resulting in muscle weakness. However, the mechanism by which DUX4 exerts its toxicity remains unclear.
Kodai Nakamura, Huascar Pedro Ortuste Quiroga, Naoki Horii, Shin Fujimaki, Toshiro Moroishi, Keiichi I. Nakayama, Shinjiro Hino, Yoshihiko Saito, Ichizo Nishino, Yusuke Ono   +9 more
doaj   +1 more source

CIC/DUX4 Fusion Protein [PDF]

, 2020
openaire   +1 more source

Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation. [PDF]

Protein Cell
Gao L, Gao Q, Hai N, Wu Z, Li P, Kang H, Song X, Hua J, Zhang S, Ren G, Yang J, Yu L, Wei Y, Ding J, Yang F.   +14 more
europepmc   +1 more source