Results 91 to 100 of about 3,790 (193)
Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics [PDF]
, 2016 Derepression of DUX4 in skeletal muscle has emerged as a likely cause of pathology in facioscapulohumeral muscular dystrophy (FSHD). Here we report on the use of antisense phosphorodiamidate morpholino oligonucleotides to suppress DUX4 expression and ...
Clayton, Nicholas P. +7 more
core +1 more source
The DUX4 cytotoxic cascade, and CRISPR mitigation methods
, 2021 Facioscapulohumeral muscular dystrophy (FSHD) is a muscle degenerative disease that disproportionally affects the muscles of the face, shoulder girdle and upper arms.
Ashoti, Ator Rafael Odisho
core
DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.
PLoS Genetics, 2013 The human double-homeodomain retrogene DUX4 is expressed in the testis and epigenetically repressed in somatic tissues. Facioscapulohumeral muscular dystrophy (FSHD) is caused by mutations that decrease the epigenetic repression of DUX4 in somatic ...
Janet M Young +9 more
doaj +1 more source
DUX4-induced histone variants H3.X and H3.Y mark DUX4 target genes for expression
, 2018 Thesis (Ph.D.)--University of Washington, 2018The DUX4 transcription factor is briefly expressed in the cleavage-stage embryo where it induces an early wave of zygotic gene transcription; whereas its mis-expression in skeletal muscle causes the muscular ...
Resnick, Rebecca May
core
TWIST2 high expression defines a novel subtype of B‐cell precursor acute lymphoblastic leukemia
HemaSphere, Volume 10, Issue 4, April 2026.
Tao Zeng +18 more
wiley +1 more source
Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene
Cell Reports, 2014 Facioscapulohumeral muscular dystrophy (FSHD) is an enigmatic disease associated with epigenetic alterations in the subtelomeric heterochromatin of the D4Z4 macrosatellite repeat.
Abhijit Dandapat +12 more
doaj +1 more source
DUX4 surexpression and silencing in a murine model [PDF]
, 2017 FSHD is a muscular dystrophy characterized by muscle atrophy. It is caused by mis-expression of DUX4 transcription factor in skeletal muscle cells. Potential therapeutic agents (AOs, siRNA) inhibiting DUX4 expression in muscles showed promising results ...
Legrand, Alexandre +5 more
core +1 more source
DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers
eLifeCancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is ...
Jose Mario Bello Pineda +1 more
doaj +1 more source
Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
wiley +1 more source
, 2013 (A) DUX4-bound regions show correlated activation levels in FSHD patient myotubes and in our DUX4-transduced myoblast experimental system. We show log2-activation levels in each system, counting RNA-seq reads within an arbitrary 1 kb of DUX4-bound ...
Zizhen Yao (48910) +9 more
core +1 more source