Results 81 to 90 of about 3,423 (190)

IntegrateALL: An end‐to‐end RNA‐seq analysis pipeline for multilevel data extraction and interpretable subtype classification in B‐precursor ALL

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Transcriptome sequencing (RNA‐seq) is emerging as a diagnostic standard for B‐cell precursor acute lymphoblastic leukemia (B‐ALL). Expression‐based classifiers reach ~95% accuracy, but reproducible end‐to‐end solutions that also integrate transcript‐derived genomic drivers and quantitative virtual karyotyping are lacking.
Nadine Wolgast, Thomas Beder, Mayukh Mondal, Wencke Walter, Stephan Hutter, Sonja Bendig, Jan Kässens, Björn‐Thore Hansen, Katharina Iben, Sebastian Wolf, Anjali Cremer, Malwine Barz, Martin Neumann, Nicola Gökbuget, Claudia Haferlach, Monika Brüggemann, Claudia D. Baldus, Alina M. Hartmann, Lorenz Bastian   +18 more
wiley   +1 more source

The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease [PDF]

Developmental Cell, 2019
In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells.
Charis L, Himeda, Peter L, Jones
openaire   +2 more sources

Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

Skeletal Muscle, 2017
Background Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle.
Premi Haynes, Kelly Kernan, Suk-Lin Zhou, Daniel G. Miller   +3 more
doaj   +1 more source

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. [PDF]

PLoS ONE, 2016
Hundreds of double homeobox (DUX) genes map within 3.3-kb repeated elements dispersed in the human genome and encode DNA-binding proteins. Among these, we identified DUX4, a potent transcription factor that causes facioscapulohumeral muscular dystrophy ...
Eugénie Ansseau, Jocelyn O Eidahl, Céline Lancelot, Alexandra Tassin, Christel Matteotti, Cassandre Yip, Jian Liu, Baptiste Leroy, Céline Hubeau, Cécile Gerbaux, Samuel Cloet, Armelle Wauters, Sabrina Zorbo, Pierre Meyer, Isabelle Pirson, Dalila Laoudj-Chenivesse, Ruddy Wattiez, Scott Q Harper, Alexandra Belayew, Frédérique Coppée   +19 more
doaj   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Comment on structural basis of DUX4/IGH-driven transactivation [PDF]

Leukemia, 2018
In a recent issue of Leukemia, Dong et al. reported the crystal structure of an isolated second homeodomain of human DUX4 (DUX4HD2) bound to a double-stranded DNA fragment (strand-1: 5’-TTCTAATCTAATCX-3’, X=A according to Materials and methods of the original paper[1], annealed with strand-2: 5’-AAGATTAGATTAGT-3’, whereas the sequence record of PDB ...
Hideki Aihara, Ke Shi, John K. Lee, Darko Bosnakovski, Michael Kyba   +4 more
openaire   +2 more sources

SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy

Skeletal Muscle
Background Facioscapulohumeral muscular dystrophy (FSHD) is a common and progressive muscle wasting disease that is characterized by muscle weakness often first noticed in the face, the shoulder girdle and upper arms before progressing to the lower limb ...
Amelia Fox, Jonathan Oliva, Rajanikanth Vangipurapu, Francis M. Sverdrup   +3 more
doaj   +1 more source

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

eLife, 2019
DUX4 is a transcription factor whose misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). DUX4’s transcriptional activity has been extensively characterized, but the DUX4-induced proteome remains undescribed.
Sujatha Jagannathan, Yuko Ogata, Philip R Gafken, Stephen J Tapscott, Robert K Bradley   +4 more
doaj   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

The DUX4-55aa protein expressed from mis-spliced DUX4 V5 mRNA does not activate apoptosis in vitro.

, 2015
(A) Western blot confirms expression of DUX4.V5, DUX4-55aa, and DUX4.HOX1.V5 constructs in HEK293 cells transfected two days earlier. The DUX4-55aa construct lacked a V5 tag, and proteins were therefore detected using rabbit anti-DUX4 primary antibodies ...
Jocelyn O. Eidahl (699964), Carlee R. Giesige (699966), Scott Q. Harper (699968), Nettie K. Pyne (699967), Susan M. Guckes (699965), Eugénie Ansseau (198885), Jacqueline S. Domire (699962), Lindsay M. Wallace (699963), Alexandra Belayew (113230)   +8 more
core   +1 more source