Results 191 to 200 of about 7,254 (221)
Some of the next articles are maybe not open access.
Anti-Cancer Drugs, 1996
After treatment of AH66DR cells with the multidrug resistance (MDR) phenotype with bovine serum albumin (BSA)-conjugated [14C]doxorubicin (DXR), accumulation of the drug in the secondary lysosomal fraction increased as a function of time up to 24 h without any significant increase of the drug in other organellae.
N, Takahashi, T, Asakura, K, Ohkawa
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After treatment of AH66DR cells with the multidrug resistance (MDR) phenotype with bovine serum albumin (BSA)-conjugated [14C]doxorubicin (DXR), accumulation of the drug in the secondary lysosomal fraction increased as a function of time up to 24 h without any significant increase of the drug in other organellae.
N, Takahashi, T, Asakura, K, Ohkawa
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Doxorubicin (DXR) modifies the density of specific atrial granules (SAGs) in dog heart
, 1987 Doxorubicin (DXR) modifies the density of specific atrial granules (SAGs) in dog ...
DANESI, ROMANO +3 more
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Functional & Integrative Genomics, 2023
The precise biological function and activity of the deoxylulose-5-phosphate reductoisomerase (DXR) gene and its promoter in Osmanthus fragrans var. semperflorens remain unclear, even though OfDXR is known as the crucial enzyme involved in plant terpenoid synthesis.
Zihan, Wang +8 more
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The precise biological function and activity of the deoxylulose-5-phosphate reductoisomerase (DXR) gene and its promoter in Osmanthus fragrans var. semperflorens remain unclear, even though OfDXR is known as the crucial enzyme involved in plant terpenoid synthesis.
Zihan, Wang +8 more
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Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr)
Journal of Medicinal Chemistry, 2011Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis.
Behrendt, Christoph T. +13 more
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International Journal of Pharmaceutics, 2006
We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of DXR in plasma was too rapid to permit the results to be extended to in vivo applications. The purpose of the study reported here is two-fold.
Tatsuhiro, Ishida +3 more
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We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of DXR in plasma was too rapid to permit the results to be extended to in vivo applications. The purpose of the study reported here is two-fold.
Tatsuhiro, Ishida +3 more
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Bioorganic & Medicinal Chemistry, 2011
The diethyl esters and disodium salts of a range of heteroarylcarbamoylphosphonic acids have been prepared and evaluated as analogues of the highly active DOXP-reductoisomerase (DXR) inhibitor, fosmidomycin. Computer-simulated docking studies, Saturation Transfer Difference (STD) NMR analysis and enzyme inhibition assays have been used to explore ...
Bodill, Taryn +4 more
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The diethyl esters and disodium salts of a range of heteroarylcarbamoylphosphonic acids have been prepared and evaluated as analogues of the highly active DOXP-reductoisomerase (DXR) inhibitor, fosmidomycin. Computer-simulated docking studies, Saturation Transfer Difference (STD) NMR analysis and enzyme inhibition assays have been used to explore ...
Bodill, Taryn +4 more
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±DXr Enklitiğinin Odaklayıcı İşlevi
Dil AraştırmalarıBu makalede, Bütün adayı bir kuş cıvıltısıdır alır (FSKAB, 83), Bir patırdıdır gidiyor (SK II, 549), İşte bir kazadır oldu (K, 156), Yine bir gülmedir tutturdular (KT, 95) gibi cümlelerde kullanılan ve bir kiplik işaretleyicisi olarak ele aldığımız ±DXr enklitiğinin “odaklayıcılık” işlevi üzerinde durulmaktadır.
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Journal of Computer-Aided Molecular Design, 2007
Mycobacterium tuberculosis 1-deoxy-D: -xylulose-5-phosphate reductoisomerase (MtDXR) is a potential target for antitubercular chemotherapy. In the absence of its crystallographic structure, our aim was to develop a structural model of MtDXR. This will allow us to gain early insight into the structure and function of the enzyme and its likely binding to
Nidhi Singh 0002 +2 more
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Mycobacterium tuberculosis 1-deoxy-D: -xylulose-5-phosphate reductoisomerase (MtDXR) is a potential target for antitubercular chemotherapy. In the absence of its crystallographic structure, our aim was to develop a structural model of MtDXR. This will allow us to gain early insight into the structure and function of the enzyme and its likely binding to
Nidhi Singh 0002 +2 more
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ON +DXr git- ~ tuttur- STRUCTURES
2017Sınırlar arasılık, fiildeki hareketin başlangıç ve bitiş sınırları arasındaki bir noktasına, süreğine yönelen görünüş türüdür. Sınırlar arasılık görünüşü, bakış noktası bakımından, gerçekleşen fiilin ortasında olmasından dolayı genellikle eş zamanlı haber bildirimleri için karakteristiktir.
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