Results 121 to 130 of about 3,215 (175)
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Dydrogesterone in threatened abortion: Pregnancy outcome
Journal of Steroid Biochemistry and Molecular Biology, 2005To determine whether therapy with dydrogesterone in threatened abortion during the first trimester of pregnancy will improve pregnancy outcome.Prospective open study.Pregnant women presenting to the obstetric and gynaecology clinic admitting center with vaginal bleeding before 13 weeks gestation were evaluated for entry into the study.
Pei Shan Lim
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Use of dydrogesterone as a progestogen for oral contraception
Steroids, 2003Dydrogesterone is a potent orally active progestogen that has been used in clinical practice for over 40 years. Chemically, it belongs to the class of retrosteroids. Dydrogesterone is closely related to endogenous progesterone. It differs from most other synthetic progestogens in that it has no estrogenic, androgenic, glucocorticoid, or anabolic ...
Herjan J T Coelingh Bennink
exaly +3 more sources
Dydrogesterone in the reduction of recurrent spontaneous abortion
Journal of Steroid Biochemistry and Molecular Biology, 2005One hundred and eighty women with a history of recurrent, unexplained spontaneous abortion (mean 3.5 abortions) were randomised to receive oral dydrogesterone (10 mg b.i.d.), intramuscular human chorionic gonadotrophin (hCG; 5000 IU every 4 days) or no additional treatment (controls).
exaly +3 more sources
Dydrogesterone and the immunology of pregnancy
Hormone Molecular Biology and Clinical Investigation, 2016Abstract Progesterone is indispensable for the maintenance of pregnancy, both via its endocrine effects and its role in creating a favorable immunological environment for the fetus. This review focuses on the immunological effects of progesterone. Progestogens have been shown to have very interesting effects on cytokine production and
Raj, Raghupathy, Julia, Szekeres-Bartho
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Dydrogesterone: metabolism in animals
European Journal of Drug Metabolism and Pharmacokinetics, 1983The metabolic pattern of dydrogesterone was investigated in the rat, dog, mouse, rabbit and rhesus monkey. The drug was administered orally in 3H-labelled form. Following enzymatic hydrolysis of conjugates the radioactive metabolites were extracted from the urine, and in rat and dog also from bile.
H, de Bree +3 more
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Dydrogesterone: Metabolism in man
European Journal of Drug Metabolism and Pharmacokinetics, 1980An investigation of the urinary metabolites of the oral progestational agent dydrogesterone in healthy women of childbearing age is reported. The drug was administered in 3H-labelled form and the urine of the first 8 h, containing on average 38% of the radioactivity administered, was used as the source of the metabolites.
P H, van Amsterdam +3 more
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DYDROGESTERONE AND ENDOMETRIOSIS
BJOG: An International Journal of Obstetrics & Gynaecology, 1976SummaryThe results are reported of the administration of dydrogesterone, 5 mg twice daily, to 49 patients with endometriosis. All but five patients were symptom‐free after nine months of therapy. Most subjective symptoms had disappeared within four to eight weeks; dyspareunia usually took longer.
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Dydrogesterone support in threatened miscarriage
Maturitas, 2009The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60).
Mazen Y, El-Zibdeh, Lama T, Yousef
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Dydrogesterone and pre-term birth
Hormone Molecular Biology and Clinical Investigation, 2016Abstract Progestin supplementation appears to be a promising approach to both preventing initiation of pre-term labor and treating it once it is already established. Successful pregnancy depends on maternal tolerance of the fetal “semi-allograft”. A protein called progesterone-induced blocking factor (PIBF), by inducing a Th2 dominant
Hudic, Igor +3 more
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Some studies of the endocrine properties of dydrogesterone
Steroids, 1966Abstract Dydrogesterone (9β, 10α-pregna-4, 6-diene-3, 20-dione; Duphaston(R) has been examined in some standard endocrine procedures. The results of these studies indicate that dydrogesterone is uterotrophic, anti-estrogenic, anti-androgenic and antigonadotropic.
A, Boris, R H, Stevenson, T, Trmal
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