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Dydrogesterone: Metabolism in man
European Journal of Drug Metabolism and Pharmacokinetics, 1980An investigation of the urinary metabolites of the oral progestational agent dydrogesterone in healthy women of childbearing age is reported. The drug was administered in 3H-labelled form and the urine of the first 8 h, containing on average 38% of the radioactivity administered, was used as the source of the metabolites.
P H, van Amsterdam +3 more
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Dydrogesterone: metabolism in animals
European Journal of Drug Metabolism and Pharmacokinetics, 1983The metabolic pattern of dydrogesterone was investigated in the rat, dog, mouse, rabbit and rhesus monkey. The drug was administered orally in 3H-labelled form. Following enzymatic hydrolysis of conjugates the radioactive metabolites were extracted from the urine, and in rat and dog also from bile.
H, de Bree +3 more
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Dydrogesterone support in threatened miscarriage
Maturitas, 2009The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60).
Mazen Y, El-Zibdeh, Lama T, Yousef
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DYDROGESTERONE AND ENDOMETRIOSIS
BJOG: An International Journal of Obstetrics & Gynaecology, 1976SummaryThe results are reported of the administration of dydrogesterone, 5 mg twice daily, to 49 patients with endometriosis. All but five patients were symptom‐free after nine months of therapy. Most subjective symptoms had disappeared within four to eight weeks; dyspareunia usually took longer.
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Dydrogesterone and pre-term birth
Hormone Molecular Biology and Clinical Investigation, 2016Abstract Progestin supplementation appears to be a promising approach to both preventing initiation of pre-term labor and treating it once it is already established. Successful pregnancy depends on maternal tolerance of the fetal “semi-allograft”.
Hudic, Igor +3 more
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Takotsubo cardiomyopathy associated with dydrogesterone use
BMJ Case Reports, 2021Takotsubo cardiomyopathy is characterised by left ventricular apical ballooning, in the absence of coronary artery disease, and classically occurs at times of intense stress. Due to the striking preponderance of Takotsubo cardiomyopathy occurring in postmenopausal women, it has been postulated that female sex hormones may also be implicated in its ...
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Dydrogesterone in threatened abortion: Pregnancy outcome
The Journal of Steroid Biochemistry and Molecular Biology, 2005To determine whether therapy with dydrogesterone in threatened abortion during the first trimester of pregnancy will improve pregnancy outcome.Prospective open study.Pregnant women presenting to the obstetric and gynaecology clinic admitting center with vaginal bleeding before 13 weeks gestation were evaluated for entry into the study.
M H, Omar +3 more
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