Results 141 to 150 of about 241,359 (260)

Palliative Care in Europe: Safeguarding Compassion Amidst Changing End-of-Life Policies and Expanding Access to Medically Assisted Dying Position Statement on behalf of the European Academy of Neurology, the European Federation of Neurological Associations and OneNeurology. [PDF]

Eur J Neurol
Rukavina K, de Visser M, Moro E, Bhatia K, Boon P, Midelfart-Hoff J, Leonardi M, Rektorova I, Fink GR, Nasr N, Gonzalez-Martinez A, Bassetti CLA, Kallweit U, Crean M, Cras P, Vanopdenbosch L, Arnesen A, Jaarsma J, Kowski AB, Veronese S, Oliver D, European Academy of Neurology, the European Federation of Neurological Associations, OneNeurology.   +23 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance. [PDF]

Cell Commun Signal
Jiang M, Yu Y, Jiao Z, Wu T, Ning K, Yang Z, Chen W, Yang A.   +7 more
europepmc   +1 more source

Dying safely [PDF]

International Journal for Quality in Health Care, 2010
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The dying-moment dream hypothesis: heaven and hell as the brain's final dream. [PDF]

Front Psychol
Kayış R.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Good care for older people at the end of life: Shared responsibilities, flexible boundaries. [PDF]

Future Healthc J
Dewhurst F, Edmonds PM, Harwood RH, Furmedge DS.   +3 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Evaluating Experiences With the Newly Enacted Law on Assisted Suicide in Austria: Protocol for an Interdisciplinary Mixed Methods Study.

JMIR Res Protoc
Doppler K, Vielgrader TL, Fischer J, Mayer H, Hluch JM, Walser M, Parrag S, Dinges S, Stöger K, Wochele-Thoma T, Kletecka-Pulker M.   +10 more
europepmc   +1 more source