Results 161 to 170 of about 314,977 (308)

General practitioners and general practitioner registrars' experiences and learning from caring for dying patients: a scoping review. [PDF]

BMJ Open
Holdsworth R, Alberti H, Burford B, Vance G.   +3 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Is the Time Right to Enact Autonomy-Only Assisted Dying Laws?

An increasing number of jurisdictions worldwide have enacted assisted dying laws allowing persons to end their lives with assistance. All existing frameworks have in common that they restrict access to persons who (1) act autonomously and (2) suffer from
Braun, Kerstin
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Mapping sources of assisted dying regulation in Belgium : a scoping review of the literature

Belgium has over 20 years of experience regulating assisted dying (AD). While much research considers this end-of-life practice, no studies have comprehensively analysed the various sources of regulation that govern it, including law, professional ...
Chambaere, KennethGE390020001958738020009676120000-0001-6277-072X32676AE8-F0EE-11E1-A9DE-61C894A0A6B4, White, Ben P, Archer, Madeleine, Deliens, LucUGent8010012873299725830854450000-0002-8158-242231DD76A8-F0EE-11E1-A9DE-61C894A0A6B4, Willmott, Lindy   +4 more
core  

Finnish physicians' attitudes towards euthanasia and physician-assisted suicide: a nationwide cross-sectional study. [PDF]

BMJ Open
Piili RP, Tolvanen E, Hökkä M, Vänskä J, Louhiala P, Lehto JT.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ethical Dilemmas in End-of-Life Care: A Psychological and Anesthetic Perspective. [PDF]

Cureus
Nmezi J.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Institutional challenges in responding to Austria's Dying Decree Law: An evaluation from the perspectives of nursing and medical directors. [PDF]

Palliat Care Soc Pract
Vielgrader TL, Hluch JM, Doppler K, Zeilinger EL, Mewes R, Parrag S, Wochele-Thoma T, Kletecka-Pulker M, Dinges S.   +8 more
europepmc   +1 more source