Results 71 to 80 of about 314,977 (308)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The therapeutic importance of the study of the effects of the near-death experience

open access: yesTheologia Viatorum
During the near-death experience (NDE), most percipients do express a high level of orderliness; yet at some instances, some percipients show some symptoms of trauma.
Agai Matthew Jock
doaj   +1 more source

THE SPIRITUAL AND MORAL CHALLENGES OF SENECTITUDE [PDF]

open access: yesStudia Warmińskie, 2016
The Christian approaching his old age faces yet another spiritual and moral challenge, just as he did throughout his life. His first moral task at this stage of life is to accept his advanced age and come to terms with the physical and psychological ...
Antoni Jucewicz
doaj  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Roles and Responsibilities of Community Pharmacists Supporting Older People with Palliative Care Needs: A Rapid Review of the Literature

open access: yesPharmacy, 2020
Globally, the number of older people requiring appropriate and safe management of medicines is growing. This review aimed to identify the roles and responsibilities of pharmacists supporting older people living in a community setting with their ...
Paul Tait   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Pediatric Nurses\u27 Death Anxiety and Level of Comfort in Approaching Families of Dying Children

open access: yes, 2011
The purpose of this study is to examine how demographics; bereavement education; personal death anxiety; and frequency of interaction with death and dying; impact the level of comfort pediatric nurses have in approaching families of dying children ...
Cook, Elizabeth J.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Why it’s important healthcare professionals talk about dying

open access: yes, 2020
This week is Dying Matters Awareness Week (May 11-17) – an awareness week led by Hospice UK to provide an opportunity to discuss the importance of talking about dying, death and bereavement.
Watson, Sharan
core  

With assisted dying now a reality, what do nurses need?

open access: yes, 2022
The End of Life Choice Act (EoLCA) 2019 has now offered a legal assisted death to eligible individuals in Aotearoa/New Zealand for 10 months. Since the legislation came into effect in November 2021, there have been progressive increased in patients ...
Carey, Melissa   +2 more
core  

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