Results 111 to 120 of about 24,196,663 (244)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Elastoplastic Dynamic Analysis and Damage Evaluation of Reinforced Concrete Structures Based on Time Histories

Buildings
In this study, the impact of seismic time histories (STHs) on structural damage was examined, focusing on maximum elastoplastic displacement (δmax) and cumulative hysteretic energy (Eh). A specialized STH Damage Analysis Program (STHDAP) was developed to
Huangbin Lin
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Cauchy problem for generalized abstract Boussinesq equations

, 2016
In this paper, the existence and uniqueness of solution of the Cauchy problem for abstract Boussinesq equations is obtained. By applying this result, the Wentzell-Robin type mixed problem for Boussinesq equations and the Cauchy problem for finite or ...
Shakhmurov,V.B.
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Dynamic Analysis of a 165Kg Spot Welding Robot

, 2011
A novel 165Kg spot welding robot is introduced, which is independently developed by China. The Newton-Euler approach is used to derive the dynamic equation. Then, entity model of the robot is built up with Solidworks software.
Chang Y(常勇), Wang HG(王洪光), Song YF(宋屹峰), Liu YW(刘玉旺), Cheng L(程丽), Luo HT(骆海涛)   +5 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Propagation and impacts on roadway of mining-induced far-field strong tremors: insights from numerical simulations

Frontiers in Earth Science
Mining-induced far-field mine tremors, which often cause strong ground tremors, are receiving more attention due to their increasing occurrence. Investigating the rock burst risk of roadway caused by those tremors is crucial to ensure production safety ...
Zepeng Han, Zepeng Han, Linming Dou, Linming Dou, Siyuan Gong, Siyuan Gong, Jinrong Cao, Jinrong Cao, Shuai Chen, Shuai Chen, Shuai Chen, Bing Hu, Yongyuan Li, Kezhi Zeng   +13 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source