Results 111 to 120 of about 6,133,725 (300)

On the Generalized Hilfer Fractional Coupled Integro-Differential Systems with Multi-Point Ordinary and Fractional Integral Boundary Conditions

Axioms
In this paper, we investigate a nonlinear coupled integro-differential system involving generalized Hilfer fractional derivative operators ((k,ψ)-Hilfer type) of different orders and equipped with non-local multi-point ordinary and fractional integral ...
Chayapat Sudprasert, Sotiris K. Ntouyas, Bashir Ahmad, Ayub Samadi, Jessada Tariboon   +4 more
doaj   +1 more source

Nonlinear dynamic analysis of an optimal particle damper

, 2011
We study the dynamical behavior of a single degree of freedom mechanical system with a particle damper. The particle (granular) damping was optimized for the primary system operating condition by using an appropriate gap size for a prismatic enclosure ...
Alligood, Bai, Bannerman, Bapat, Blazejczyk-Okolewska, Brilliantov, C. Manuel Carlevaro, Cundall, Duncan, Fang, Fraser, Friend, Grubin, Hegger, Holmes, Kantz, Kantz, Kennel, Kruggel-Emden, Kruggel-Emden, Luck, Mao, Marhadi, Martín Sánchez, Masri, Panossian, Pastor, Peterka, Pöschel, Ramachandran, Rao, Sadek, Saeki, Salueña, Sauer, Schäfer, Strogatz, Sung, Sánchez, Sánchez, Sánchez, Xia, Xu   +42 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

MonoBot: A Single-Actuator Walking Robot

IEEE Access
This paper introduces the design and analysis of novel planar mobile robot operated by a single actuator. Distinct from conventional multi-actuator designs, this robot achieves both walking and turning motions through a single actuator mechanism, thereby
Uriya Lax, Oded Medina, Nir Shvalb
doaj   +1 more source

Analysis of Performance of Dynamic Multicast Routing Algorithms

, 1998
In this paper, three new dynamic multicast routing algorithms based on the greedy tree technique are proposed; Source Optimised Tree, Topology Based Tree and Minimum Diameter Tree. A simulation analysis is presented showing various performance aspects of
Ballardie, Bharathi-Kumar, Cho, Deering, Donahoo, Hu, Imase, J Breen, J Cho, Kompella, Kou, Magnanti, Makki, Rosenkrantz, Rouskas, Waxman, Waxman   +16 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Elastoplastic Dynamic Analysis and Damage Evaluation of Reinforced Concrete Structures Based on Time Histories

Buildings
In this study, the impact of seismic time histories (STHs) on structural damage was examined, focusing on maximum elastoplastic displacement (δmax) and cumulative hysteretic energy (Eh). A specialized STH Damage Analysis Program (STHDAP) was developed to
Huangbin Lin
doaj   +1 more source