Results 151 to 160 of about 31,271,570 (411)

Propagation and impacts on roadway of mining-induced far-field strong tremors: insights from numerical simulations

open access: yesFrontiers in Earth Science
Mining-induced far-field mine tremors, which often cause strong ground tremors, are receiving more attention due to their increasing occurrence. Investigating the rock burst risk of roadway caused by those tremors is crucial to ensure production safety ...
Zepeng Han   +13 more
doaj   +1 more source

Dynamic Response Analysis of Solar Array of a Satellite

open access: yes, 2017
The dynamic response analysis to simulate the complicated working condition can ensure the high reliability of space products' design. In this paper, we focus on the solar array of a satellite, and gain equivalent mechanical parameters of its ...
Wang W(王巍)   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Evaluation of Seismic Response of the Cross-Laminated Timber (CLT) Multi-Storey Residential Building Under the February 6, 2023, Kahramanmaraş Earthquakes

open access: yesJournal of Architectural Sciences and Applications
The February 6, 2023 Kahramanmaraş earthquakes exposed the vulnerabilities of existing RC structures, causing thousands of buildings to collapse or sustain severe damage, especially in the hardest-hit provinces.
Gülten Tandoğan Kibar   +2 more
doaj   +1 more source

Design and inverse dynamic analysis of a humanoid robot

open access: yes, 2004
In this paper we first present the mechanism system configuration, basic control structure of a humanoid robot constructed by our laboratory The human-sized robot has an all-orientation wheel mobile vehicle with 3-DOF, two 7-DOF arms, one 2-DOF neck and ...
Tan DL(谈大龙)   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Dynamic Financial Analysis - Understanding Risk and Value Creation in Insurance [PDF]

open access: yes
The changing business environment in non-life insurance and reinsurance has raised the need for new quantitative methods to analyze the impact of various types of strategic decisions on a company’s bottom line.
Michel Dacorogna, Peter Blum
core  

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