Results 141 to 150 of about 31,271,570 (411)

Elastoplastic Dynamic Analysis and Damage Evaluation of Reinforced Concrete Structures Based on Time Histories

open access: yesBuildings
In this study, the impact of seismic time histories (STHs) on structural damage was examined, focusing on maximum elastoplastic displacement (δmax) and cumulative hysteretic energy (Eh). A specialized STH Damage Analysis Program (STHDAP) was developed to
Huangbin Lin
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Dynamic analysis of 7-DOF exoskeleton upper-limbed rehabilitation robot

open access: yes, 2015
Dynamic analysis has been playing a significant role in 7-DOF exoskeleton upper-limbed rehabilitation robot, which usually affects the choice of measurement and optimization.
Fang, Jiajia   +6 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Parameter sensitivity study of dynamic response for jack-ups by FEM analysis

open access: yes, 2016
Jack-up platforms will generally behave as highly dynamic systems because of the structure flexibility. The environmental forces acting on these jack-ups will therefore induce significant dynamic response.
Nie, Wenjun   +6 more
core  

Analysis of dynamic contact forces for forging manipulator grippers

open access: yes, 2010
A contact model has been presented which assume that the contact forces between the work-piece and the tongs are simplified as the four resultant forces with friction point contact. And the contact forces are calculated based on this contact model.
Hua Deng   +5 more
core   +1 more source

Analysis of Design Process Dynamics.

open access: yes, 2004
To enable the development of automated support for design, a challenge is to model and analyse dynamics of design processes in a formal manner. This paper contributes a declarative, logical approach for specification of dynamic properties of design processes, supported by a formal temporal language.
Bosse, T., Jonker, C.M., Treur, J.
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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