Dynamic analysis of dissipative structures undergoing parametric changes
Incertitudes et Fiabilité des Systèmes Multiphysiques, 2021 Omar Dadah +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An analytical investigation to the (3+1)-dimensional Yu–Toda–Sassa–Fukuyama equation with dynamical analysis: Bifurcation [PDF]
Rajib Mia +5 more
openalex +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Effect of Rope Jumping Training on The Dynamic Balance Ability and Hitting Stability among Adolescent Tennis Players: A Systematic Analysis of Randomized Controlled Trials [PDF]
, 2023 Zuozheng Shi +5 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Analysis and Design of a Personalized Recommendation System Based on a Dynamic User Interest Model [PDF]
Chen Mao +4 more
openalex +1 more source
Dynamic Factor Analysis with ARMA Factors [PDF]
In this paper we present a new approach to the specification of dynamic factor models. Our model has three advantages over existing work. Firstly, it is based on a minimal-dimension state-space representation giving some gain in computational efficiency ...
Chris Heaton, Victor Solo
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Structure-Function Analysis of the Heat Shock Factor-binding Protein Reveals a Protein Composed Solely of a Highly Conserved and Dynamic Coiled-coil Trimerization Domain [PDF]
, 2002 Li-Jung Tai +7 more
openalex +1 more source