Results 61 to 70 of about 288,872 (253)

Dynamic Capabilities and Performance: Strategy, Structure and Environment [PDF]

Long Range Planning, 2013
Dynamic capabilities are widely considered to incorporate those processes that enable organizations to sustain superior performance over time. In this paper, we argue theoretically and demonstrate empirically that these effects are contingent on organizational structure and the competitive intensity in the market.
Wilden, Ralf, Gudergan, Siegfried P., Nielsen, Bo Bernhard, Lings, Ian   +3 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Decoding the Factors of Electric Vehicle Supply Chain Resilience: A Structured Categorization for Enhancing Resilience Through Factor Synergies

IEEE Access
This study focuses on building resilience in electric vehicle (EV) supply chain to address the growing challenges of global market uncertainties. Grounded in dynamic capabilities theory, the study identifies and categorizes 16 key factors influencing ...
Yanxuan Li, Vatcharapol Sukhotu
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamic capabilities and innovation capabilities: The case of the ‘Innovation Clinic’ [PDF]

Journal of Entrepreneurship, Management and Innovation, 2017
In this explorative study, we investigate the relationship between dynamic capabilities and innovation capabilities. Dynamic capabilities are at the core of strategic management in terms of how firms can ensure adaptation to changing environments over time. Our paper follows two paths of argumentation.
Strønen, Fred, Hoholm, Thomas, Kværner, Kari, Støme, Linn Nathalie   +3 more
openaire   +6 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Effect of resource integration on organizational resilience of megaprojects: role of dynamic capability and resource availability

Journal of Asian Architecture and Building Engineering
Organizational resilience is an important factor for megaprojects to adapt to dynamic and complex environments. This study aims to explore the relationship between the resource integration mechanism and organizational resilience from the perspectives of ...
Dedong Wang, Xiaoru Zhao
doaj   +1 more source

Design Driven Innovation as a Differentiation Strategy - in the Context of Automotive Industry

Journal of Technology Management & Innovation, 2015
Though, in the automotive industry, technology is considered as a source of innovation and development, emerging change in consumer perception has brought industry focus on design.
Mosarrat Farhana, Eric Bimenyimana
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source