Results 121 to 130 of about 5,911,579 (291)

CTMNet: causal trend evolution and adaptive modulation for time series forecasting

Scientific Reports
In multivariate time series forecasting, series decomposition architectures that decouple trend and residual components have become a mainstream solution for handling data non-stationarity.
Yihao Wang, Xiao Chen, Jing Chen, MingXin Liu   +3 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Searching multiregression dynamic models of resting-state fMRI networks using integer programming [PDF]

, 2015
A Multiregression Dynamic Model (MDM) is a class of multivariate time series that represents various dynamic causal processes in a graphical way. One of the advantages of this class is that, in contrast to many other Dynamic Bayesian Networks, the ...
Smith, Jim, Cussens, James, Duff, Eugene P., Nichols, Thomas, Makin, Tamar, Costa, Lilia, Smith, J. Q., Duff, Eugene, Makin, Tamar R., Nichols, Thomas E.   +9 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

On Granger-causality and the effect of interventions in time series [PDF]

We combine two approaches to causal reasoning. Granger-causality, on the one hand, is popular in fields like econometrics, where randomised experiments are not very common.
Didelez, Vanessa, Eichler, Michael
core  

Dynamic Causal Modeling of the Response to Frequency Deviants

, 2009
This article describes the use of dynamic causal modeling to test hypotheses about the genesis of evoked responses. Specifically, we consider the mismatch negativity (MMN), a well-characterized response to deviant sounds and one of the most widely ...
Friston, K., Kilner, J., Kilner, James M., Garrido, Marta I., Kiebel, Stefan J., Garrido, M., Friston, Karl J., Kiebel, S.   +7 more
core   +1 more source

Causal modeling & dynamical systems:A new perspective on feedback [PDF]

, 2022
In this thesis, Causal Modeling & Dynamical Systems: A New Perspective On Feedback, we propose novel solutions to causal modeling in the presence of latent confounding (“latent common causes”) and cyclic causal relationships (“feedback loops”).
Bongers, S.R.
core