Results 81 to 90 of about 5,911,579 (291)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Causal hierarchy within the thalamo-cortical network in spike and wave discharges [PDF]

, 2009
Background: Generalised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption of ongoing activities and impaired consciousness, occurring during states of ...
Lemieux, L., Vaudano, Anna E., Friston, KJ, Rodionov Roman, Carmichael, D., Thornton, R., Thornton, Rachel, Lemieux, Louis, VAUDANO, Anna Elisabetta, Maxime Guye, Vaudano, A., Anna E Vaudano, Carmichael, David W., Hamandi, K., Carmichael David W., Kiebel, SJ, Carmichael, DW, Vaudano Anna E., Vaudano, AE, Guye, M, Hamandi, K, Thornton Rachel, Guye Maxime, Duncan, JS, de la Prida, Liset Menendez, Friston Karl J., Louis Lemieux, Stefan J Kiebel, Rachel Thornton, Rodionov, R, David W Carmichael, Khalid Hamandi, Friston, Karl J., Thornton, R, Guye, M., Kiebel, Stefan J., Duncan, John S., Rodionov, Roman, Duncan, J., Duncan John S., Lemieux, L, Roman Rodionov, Hamandi Khalid, Kiebel, S., Hamandi, Khalid, Lemieux Louis, Friston, K., Rodionov, R., Laufs, H, Laufs, Helmut, Helmut Laufs, Laufs, H., John S Duncan, Laufs Helmut, Guye, Maxime, Karl J Friston, Kiebel Stefan J.   +56 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

An afferent white matter pathway from the pulvinar to the amygdala facilitates fear recognition

eLife, 2019
Our ability to rapidly detect threats is thought to be subserved by a subcortical pathway that quickly conveys visual information to the amygdala.
Jessica McFadyen, Jason B Mattingley, Marta I Garrido   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A dynamic causal model study of neuronal population dynamics

NeuroImage, 2010
In this paper, we compare mean-field and neural-mass models of electrophysiological responses using Bayesian model comparison. In previous work, we presented a mean-field model of neuronal dynamics as observed with magnetoencephalography and electroencephalography. Unlike neural-mass models, which consider only the mean activity of neuronal populations,
André C. Marreiros, Stefan J. Kiebel, Karl J. Friston   +2 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Application of System-Dynamic Modeling to Improve Distribution Logistics Processes in the Supply Chain

, 2020
This article presents an approach of improve logistics processes with the system dynamics modeling of two different processes scenarios. System dynamics is used, not only as a causal loop diagram, but calculated measures of end-user satisfaction ...
Sayabek Ziyadin, Askhat Serikbekuly, Galimkair Mutanov   +2 more
core   +1 more source

Inversion-based control of electromechanical systems using causal graphical descriptions [PDF]

, 2006
Causal Ordering Graph and Energetic Macroscopic Representation are graphical descriptions to model electromechanical systems using integral causality. Inversion rules have been defined in order to deduce control structure step-bystep from these graphical
F. Giraud, BOUSCAYROL, Alain, GIRAUD, Frédéric, HAUTIER, Jean-Paul, A. Bouscayrol, DELARUE, Philippe, J. P. Hautier, P. Delarue, E. Semail, B. Lemaire-Semail, KESTELYN, Xavier, P. J. Barrre, BARRE, Pierre-Jean, LEMAIRE-SEMAIL, Betty, SEMAIL, Eric, E. Dumetz, X. Kestelyn, DUMETZ, Eric   +17 more
core   +1 more source