Results 41 to 50 of about 21,276,656 (224)

Solving Fuzzy Multiple Objective Dynamic Cellular Manufacturing System Problem using a Hybrid Algorithm of NSGA-II and Progressive Simulated Annealing [PDF]

چشم‌انداز مدیریت صنعتی, 2014
Cellular manufacturing systems (CMSs) are as one of the most important manufacturing methods.In this paper, is presented a multiple objective model to constitute a CMS under dynamic conditions subject to flexibility of operation processing, assigning ...
Alireza Alinezhad, Sajjad Sabet, Mostafa Ekhtiari   +2 more
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Machine Reliability in a Dynamic Cellular Manufacturing System: A Comprehensive Approach to a Cell Layout Problem

International Journal of Industrial Engineering and Production Research, 2018
The fundamental function of a cellular manufacturing system (CMS) is based on definition and recognition of a type of similarity among parts that should be produced in a planning period.
Amir-Mohammad Golmohammadi, Mahboobeh Honarvar, Hasan Hosseini-Nasab, Reza Tavakkoli-MOghaddam   +3 more
doaj   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Scheduling of Virtual Cellular Manufacturing Systems: A Biogeography-Based Optimization Algorithm

Applied Artificial Intelligence, 2019
Virtual cellular manufacturing system (VCMS) is one of the modern strategies in the production facilities layout, which has attracted considerable attention in recent years.
M. Zandieh
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A control methodology for automated manufacturing [PDF]

, 1991
The application of computers in the manufacturing industry has substantially altered the control procedures used to program a whole manufacturing process. Currently, one the problems which automated manufacturing systems are experiencing is the lack of a
Nahavandi, Saeid
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Comprehensive Mathematical Model for the Design of a Dynamic Cellular Manufacturing System Integrated with Production Planning and Several Manufacturing Attributes

International Journal of Industrial Engineering and Production Research, 2011
Dynamic cellular manufacturing systems,   Mixed-integer non-linear programming,   Production planning, Manufacturing attributes   This paper presents a novel mixed-integer non-linear programming model for the design of a dynamic cellular manufacturing ...
F. Khaksar-Haghani, N. Javadian, R. Tavakkoli-Moghaddam, A. Baboli, R. Kia   +4 more
doaj